Detailed information of TA system TA209181

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2561671..2562109
• Replicon: chromosome
• Accession: NZ_CP078162
• Organism: Enterococcus faecalis strain NS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: KVY10_RS12070
• Protein ID: WP_002396786.1
• Coordinates: 2561966..2562109 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2561671..2561872 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY10_RS12045	2556868..2557860	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
KVY10_RS12050	2558124..2558762	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
KVY10_RS12055	2559449..2561065	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
KVY10_RS12060	2561297..2561479	+	183	WP_002424907.1	type I toxin-antitoxin system toxin PepG1	-
KVY10_RS12065	2561598..2561738	+	141	WP_073340360.1	putative holin-like toxin	-
-	2561671..2561872	-	202	-	-	Antitoxin
KVY10_RS12070	2561966..2562109	+	144	WP_002396786.1	putative holin-like toxin	Toxin
KVY10_RS12075	2562304..2566995	-	4692	WP_218391326.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T209181 WP_002396786.1 NZ_CP078162:2561966-2562109 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T209181 NZ_CP103889:2402042-2402461 [Corynebacterium diphtheriae bv. gravis]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA

Antitoxin

Nucleotide

• Length: 202 bp

>AT209181 NZ_CP078162:c2561872-2561671 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAACAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin