Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2561453..2561738 Replicon chromosome
Accession NZ_CP078162
Organism Enterococcus faecalis strain NS2

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag KVY10_RS12065 Protein ID WP_073340360.1
Coordinates 2561598..2561738 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2561453..2561596 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVY10_RS12040 2556514..2556729 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
KVY10_RS12045 2556868..2557860 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
KVY10_RS12050 2558124..2558762 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
KVY10_RS12055 2559449..2561065 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
KVY10_RS12060 2561297..2561479 + 183 WP_002424907.1 type I toxin-antitoxin system toxin PepG1 -
- 2561453..2561596 - 144 - - Antitoxin
KVY10_RS12065 2561598..2561738 + 141 WP_073340360.1 putative holin-like toxin Toxin
KVY10_RS12070 2561966..2562109 + 144 WP_002396786.1 putative holin-like toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T209177 WP_073340360.1 NZ_CP078162:2561598-2561738 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

>T209177 NZ_CP103872:3826793-3826975 [Herbaspirillum huttiense]
ATGGACAGCGCAACCCTCATCAAACGACTCAAGGCCGACGGCTGGGAGCTGGTGCATACGGTCGGCTCACACCACCAGTT
CAAGCACCCGAGCAAGCGCGGCAAGGTGACGGTGCCACATCCGAAGAAGGATCTGCCGCTGCCGACGCAGAACAGCATTC
TCAAGCAAGCCGGCCTGAAGTGA

Antitoxin


Download         Length: 144 bp

>AT209177 NZ_CP078162:c2561596-2561453 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References