Detailed information of TA system TA209170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2561297..2561596
• Replicon: chromosome
• Accession: NZ_CP078162
• Organism: Enterococcus faecalis strain NS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A8B3RWV6
• Locus tag: KVY10_RS12060
• Protein ID: WP_002424907.1
• Coordinates: 2561297..2561479 (+)
• Length: 61 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2561412..2561596 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY10_RS12040	2556514..2556729	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
KVY10_RS12045	2556868..2557860	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
KVY10_RS12050	2558124..2558762	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
KVY10_RS12055	2559449..2561065	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
KVY10_RS12060	2561297..2561479	+	183	WP_002424907.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2561412..2561596	-	185	-	-	Antitoxin
KVY10_RS12065	2561598..2561738	+	141	WP_073340360.1	putative holin-like toxin	-
KVY10_RS12070	2561966..2562109	+	144	WP_002396786.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (27-60)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6952.45 Da
• Isoelectric Point: 11.0738

>T209170 WP_002424907.1 NZ_CP078162:2561297-2561479 [Enterococcus faecalis]
MAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 183 bp

>T209170 NZ_CP103871:763897-764154 [Actinacidiphila bryophytorum]
GTGAAGACGATGTCGTACTCGGAGTCGCGGGCGAAGTACGCCGAGGTGCTGAACAGCGTGACCGACGACCGGGAAGAGGT
CGTGATCACGCGGGCCGGGCACGATCCGGTGGTCATCGTGTCGCTGGAGGACTACGAGTCGCTGAAGGAGACCGCCTACC
TGCTGCGCAGCCCCGCCAACGCGCGGCGGCTGCTCGCCTCCATCGAGGAGCTGGAGAGCGGCGGCGGGACCGTACGGGAG
CTGGCGGAGGAGGAGTGA

Antitoxin

Nucleotide

• Length: 185 bp

>AT209170 NZ_CP078162:c2561596-2561412 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A8B3RWV6

Antitoxin