Detailed information of TA system TA209166

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2485650..2486112
• Replicon: chromosome
• Accession: NZ_CP078162
• Organism: Enterococcus faecalis strain NS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KVY10_RS11725
• Protein ID: WP_002367458.1
• Coordinates: 2485650..2485793 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2485958..2486112 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY10_RS11710	2483181..2483831	+	651	WP_218391305.1	beta-phosphoglucomutase	-
KVY10_RS11715	2484199..2484303	-	105	WP_256356963.1	putative holin-like toxin	-
KVY10_RS11720	2484817..2485410	+	594	WP_002385181.1	PBECR4 domain-containing protein	-
KVY10_RS11725	2485650..2485793	-	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2485958..2486112	+	155	-	-	Antitoxin
KVY10_RS13040	2486202..2486327	-	126	WP_010821164.1	hypothetical protein	-
KVY10_RS11730	2486609..2487142	+	534	WP_002385180.1	CPBP family intramembrane metalloprotease	-
KVY10_RS11735	2487195..2488166	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
KVY10_RS11740	2488341..2488778	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
KVY10_RS11745	2488911..2489465	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T209166 WP_002367458.1 NZ_CP078162:c2485793-2485650 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T209166 NZ_CP103865:c34357-34052 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 155 bp

>AT209166 NZ_CP078162:2485958-2486112 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGA
CGGTGACCATGTTAATTATTTAAAAATAACCGTGCTTGGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAA

Structures

Antitoxin