Detailed information of TA system TA209160

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2484199..2484530
• Replicon: chromosome
• Accession: NZ_CP078162
• Organism: Enterococcus faecalis strain NS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KVY10_RS11715
• Protein ID: WP_256356963.1
• Coordinates: 2484199..2484303 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2484455..2484530 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY10_RS11700	2479447..2480160	-	714	WP_002367455.1	trehalose operon repressor	-
KVY10_RS11705	2480422..2483166	+	2745	WP_218391304.1	glycosyl hydrolase family 65 protein	-
KVY10_RS11710	2483181..2483831	+	651	WP_218391305.1	beta-phosphoglucomutase	-
KVY10_RS11715	2484199..2484303	-	105	WP_256356963.1	putative holin-like toxin	Toxin
-	2484455..2484530	+	76	-	-	Antitoxin
KVY10_RS11720	2484817..2485410	+	594	WP_002385181.1	PBECR4 domain-containing protein	-
KVY10_RS11725	2485650..2485793	-	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	-
KVY10_RS13040	2486202..2486327	-	126	WP_010821164.1	hypothetical protein	-
KVY10_RS11730	2486609..2487142	+	534	WP_002385180.1	CPBP family intramembrane metalloprotease	-
KVY10_RS11735	2487195..2488166	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
KVY10_RS11740	2488341..2488778	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
KVY10_RS11745	2488911..2489465	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T209160 WP_256356963.1 NZ_CP078162:c2484303-2484199 [Enterococcus faecalis]
MSAYETIQTLLGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

>T209160 NZ_CP103864:4266728-4267102 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 76 bp

>AT209160 NZ_CP078162:2484455-2484530 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACC

Structures

Antitoxin