Detailed information of TA system TA209153

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2411509..2411766
• Replicon: chromosome
• Accession: NZ_CP078162
• Organism: Enterococcus faecalis strain NS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KVY10_RS11375
• Protein ID: WP_021164441.1
• Coordinates: 2411665..2411766 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2411509..2411716 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY10_RS11350	2407193..2408146	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
KVY10_RS11355	2408185..2408940	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KVY10_RS11360	2408937..2409902	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
KVY10_RS11365	2409899..2410846	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
KVY10_RS11370	2411031..2411483	+	453	WP_002378959.1	YueI family protein	-
-	2411509..2411716	+	208	-	-	Antitoxin
KVY10_RS11375	2411665..2411766	-	102	WP_021164441.1	putative holin-like toxin	Toxin
KVY10_RS11380	2411956..2414226	-	2271	WP_218391297.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KVY10_RS11385	2414397..2414897	+	501	WP_033596189.1	cysteine hydrolase family protein	-
KVY10_RS11390	2415349..2416245	+	897	WP_002368434.1	YitT family protein	-
KVY10_RS11395	2416295..2416693	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T209153 WP_021164441.1 NZ_CP078162:c2411766-2411665 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T209153 NZ_CP103864:2577833-2578183 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT209153 NZ_CP078162:2411509-2411716 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin