Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 451286..451788 Replicon chromosome
Accession NZ_CP078145
Organism Nocardia iowensis strain NRRL 5646

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KV110_RS02170 Protein ID WP_218472869.1
Coordinates 451531..451788 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KV110_RS02165 Protein ID WP_218472868.1
Coordinates 451286..451534 (+) Length 83 a.a.

Genomic Context

KV110_RS02135KV110_RS02150KV110_RS02155KV110_RS02160KV110_RS02165KV110_RS02170KV110_RS02185KV110_RS02140KV110_RS02145KV110_RS02175KV110_RS02180KV110_RS02190
Location: 446725..447297 (573 bp)
Type: Others
Protein ID: WP_218472860.1
Location: 448323..448784 (462 bp)
Type: Others
Protein ID: WP_218472865.1
Location: 448868..450133 (1266 bp)
Type: Others
Protein ID: WP_014981150.1
Location: 450137..451171 (1035 bp)
Type: Others
Protein ID: WP_218472866.1
Location: 451286..451534 (249 bp)
Type: Antitoxin
Protein ID: WP_218472868.1
Location: 451531..451788 (258 bp)
Type: Toxin
Protein ID: WP_218472869.1
Location: 455191..456105 (915 bp)
Type: Others
Protein ID: WP_218472872.1
Location: 447309..447725 (417 bp)
Type: Others
Protein ID: WP_218472862.1
Location: 447744..448226 (483 bp)
Type: Others
Protein ID: WP_218472863.1
Location: 451862..454303 (2442 bp)
Type: Others
Protein ID: WP_218472870.1
Location: 454444..455058 (615 bp)
Type: Others
Protein ID: WP_218472871.1
Location: 456138..456767 (630 bp)
Type: Others
Protein ID: WP_218472873.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KV110_RS02135 (KV110_02135)446725..447297+573WP_218472860.1dihydrofolate reductase family protein-
KV110_RS02140 (KV110_02140)447309..447725-417WP_218472862.1secondary thiamine-phosphate synthase enzyme YjbQ-
KV110_RS02145 (KV110_02145)447744..448226-483WP_218472863.1MarR family transcriptional regulator-
KV110_RS02150 (KV110_02150)448323..448784+462WP_218472865.1SgcJ/EcaC family oxidoreductase-
KV110_RS02155 (KV110_02155)448868..450133+1266WP_014981150.1aspartate kinase-
KV110_RS02160 (KV110_02160)450137..451171+1035WP_218472866.1aspartate-semialdehyde dehydrogenase-
KV110_RS02165 (KV110_02165)451286..451534+249WP_218472868.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
KV110_RS02170 (KV110_02170)451531..451788+258WP_218472869.1Txe/YoeB family addiction module toxinToxin
KV110_RS02175 (KV110_02175)451862..454303-2442WP_218472870.1glycoside hydrolase family 3 C-terminal domain-containing protein-
KV110_RS02180 (KV110_02180)454444..455058-615WP_218472871.1TetR/AcrR family transcriptional regulator-
KV110_RS02185 (KV110_02185)455191..456105+915WP_218472872.1aminotransferase class IV-
KV110_RS02190 (KV110_02190)456138..456767-630WP_218472873.1TetR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-69)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10059.69 Da        Isoelectric Point: 8.8975

>T209121 WP_218472869.1 NZ_CP078145:451531-451788 [Nocardia iowensis]
MRLIFSESAWEEYTAWLQRDRTVLKKVNVLIKAIMCDPFEGIGKPEPLKHDLAGYWSRRITQEHRIVYKVVEDALWIAKG
GKHYE

Download         Length: 258 bp

>T209121 NZ_CP103852:c1976843-1975506 [Ralstonia pseudosolanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCCCGTCGGCATCTGGACAGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGCCTGGTTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCGATCCGCGAGCGCGTGCGG
CGCCGCTTCAGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCGCCCACCGGCTACGACCGCATCGACAGCGAGCCGCTCACAGACAGCCAGGTCGACGCGCTGC
TGCGCAATCTCACCGCCACACCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAGACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAACTGC
TGACGGCCTGGGGGCTGGAGGTGGCGCACACCGAGATGGCTCGCTTCGGCACCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATATGAAAACGACGGCGGCCCCGGCATGCGCACCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTGGCCGCCACCGACGGGCACGCGAAAAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGTTTCCGCATGACGCCGCTGTACGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGACCGACA
TCCACCTGCGCCACTGGCAGGCGCTGGCGGCACAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCTGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGACCAGGTCGAGGCGATCCTGCCGCACGACTTCTCCGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGACCGAGCGCTTTCTCACCGAACTGGCGTCCGTCACCCCATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8823.97 Da        Isoelectric Point: 4.7769

>AT209121 WP_218472868.1 NZ_CP078145:451286-451534 [Nocardia iowensis]
MAAAITASEARKHLFPLVKQVNEDHDTIEIVSKGGNAVLMSKEDYDSLMTTVQLLSGPDGARLRRSIQELEGGGGTGREL
IE

Download         Length: 249 bp

>AT209121 NZ_CP103852:c1977101-1976847 [Ralstonia pseudosolanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGTTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAACTGGGCGCGTTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTGCTGCGCATCCTGCACGCGCTCGGCGCGCAGCTGACGCTGCGCACGTCCGCACCCGCCGGCGGCCCCTCCGCCGCG
CCCGCCGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References