Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4718802..4719556 | Replicon | chromosome |
| Accession | NZ_CP078142 | ||
| Organism | Salmonella enterica subsp. diarizonae strain LHICA_D1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | JMJ85_RS22600 | Protein ID | WP_000558166.1 |
| Coordinates | 4718802..4719113 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JMJ85_RS22605 | Protein ID | WP_001259011.1 |
| Coordinates | 4719110..4719556 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMJ85_RS22570 (4714471) | 4714471..4715373 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| JMJ85_RS22575 (4715370) | 4715370..4716005 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| JMJ85_RS22580 (4716002) | 4716002..4716931 | + | 930 | WP_053509958.1 | formate dehydrogenase accessory protein FdhE | - |
| JMJ85_RS22585 (4716969) | 4716969..4717343 | - | 375 | WP_023249114.1 | type II toxin-antitoxin system VapC family toxin | - |
| JMJ85_RS22590 (4717343) | 4717343..4717585 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| JMJ85_RS22595 (4717790) | 4717790..4718716 | + | 927 | Protein_4450 | alpha/beta hydrolase | - |
| JMJ85_RS22600 (4718802) | 4718802..4719113 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| JMJ85_RS22605 (4719110) | 4719110..4719556 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| JMJ85_RS22610 (4719571) | 4719571..4720512 | - | 942 | WP_024134888.1 | fatty acid biosynthesis protein FabY | - |
| JMJ85_RS22615 (4720557) | 4720557..4720994 | - | 438 | WP_023249111.1 | D-aminoacyl-tRNA deacylase | - |
| JMJ85_RS22620 (4720991) | 4720991..4721863 | - | 873 | WP_023249110.1 | virulence factor BrkB family protein | - |
| JMJ85_RS22625 (4721857) | 4721857..4722456 | - | 600 | WP_000965699.1 | glucose-1-phosphatase | - |
| JMJ85_RS22630 (4722647) | 4722647..4723450 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| JMJ85_RS22635 (4723484) | 4723484..4724380 | - | 897 | WP_111764805.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T209119 WP_000558166.1 NZ_CP078142:4718802-4719113 [Salmonella enterica subsp. diarizonae]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T209119 NZ_CP103852:c1293438-1293025 [Ralstonia pseudosolanacearum]
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGACTTGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGACTTGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT209119 WP_001259011.1 NZ_CP078142:4719110-4719556 [Salmonella enterica subsp. diarizonae]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT209119 NZ_CP103852:c1293686-1293435 [Ralstonia pseudosolanacearum]
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|