Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 354291..354937 Replicon chromosome
Accession NZ_CP078122
Organism Klebsiella pneumoniae strain KPC-2

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag KU889_RS01635 Protein ID WP_002920560.1
Coordinates 354291..354638 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag KU889_RS01640 Protein ID WP_002920557.1
Coordinates 354638..354937 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU889_RS01625 350217..351650 + 1434 WP_002920564.1 glycogen synthase GlgA -
KU889_RS01630 351668..354115 + 2448 WP_002920561.1 glycogen phosphorylase -
KU889_RS01635 354291..354638 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KU889_RS01640 354638..354937 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
KU889_RS01645 355000..356508 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
KU889_RS01650 356713..357042 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KU889_RS01655 357093..357923 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KU889_RS01660 357973..358731 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T209039 WP_002920560.1 NZ_CP078122:354291-354638 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T209039 NZ_CP103809:2109190-2109522 [Actinobacillus genomosp. 1]
ATGAAGCGTGGCGATGTGTATTGGCTTGATCTTAATCCGACATTAGGGCATGAGCAGGCCGGATGCCGTCCGGTTGTAAT
TGTATCTGCAACGGCATTTAATCTGGCGAGTAAATTGCCTGTCGTGGTACCGATTACAAACGGCGGTGCATTTGCCGAAC
GACTTGGCTTTGCGGTTTCGTTACAAAATAGTGGCTTAAAAACGACAGGGATAGTACGTTGTGACCAACCTCGTACGGTA
GATATTATTCAGCGTAACGGTAAATTTATTGAAGTGTTACCTGAAGATTTACTTGATGAGGTAATGGCGAGAGTTTCCGT
TATTTTTGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT209039 WP_002920557.1 NZ_CP078122:354638-354937 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT209039 NZ_CP103809:2108933-2109193 [Actinobacillus genomosp. 1]
ATGCCAACAGTTGCATTACGTCAAGTCGGCGGATCCGTTGCGATGGTTATCCCACCGGCTTTTCTACAAGCTCTCAATCT
TTCGGTTGGAAGTAAGGTGGATTTATCTTTGAGTGAAGAAAAGCTAGTGATAAATCCTGTTAGACCAAAAGTAAAATATA
GCCTTGAAGAATTGTTAAATCGGTCTGATTTTGAATCGGCAAGAACAGAAGAAAGTCAGATATGGTTGGATGCACCTCAA
GTTGGAAATGAGATCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References