Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 328102..328688 Replicon chromosome
Accession NZ_CP078122
Organism Klebsiella pneumoniae strain KPC-2

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KU889_RS01525 Protein ID WP_002920800.1
Coordinates 328320..328688 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag KU889_RS01520 Protein ID WP_002920802.1
Coordinates 328102..328323 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU889_RS01500 324259..325185 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KU889_RS01505 325182..326459 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
KU889_RS01510 326456..327223 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KU889_RS01515 327225..327938 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KU889_RS01520 328102..328323 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU889_RS01525 328320..328688 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KU889_RS01530 328961..330277 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KU889_RS01535 330384..331271 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KU889_RS01540 331268..332113 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KU889_RS01545 332115..333185 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 326456..333922 7466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T209038 WP_002920800.1 NZ_CP078122:328320-328688 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T209038 NZ_CP103809:1954960-1955358 [Actinobacillus genomosp. 1]
ATGCTAGCTTATATGCTTGATACTAATATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTATTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACAGCGGCTGAGCTGTATTACGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCACGGTAAAATTATCAGGGAGAACGATATTCATGTTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACTAATAACTTACGTGAATTTGAACGTGTAGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT209038 WP_002920802.1 NZ_CP078122:328102-328323 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT209038 NZ_CP103809:1954730-1954960 [Actinobacillus genomosp. 1]
ATGGAAGCATCAGTATTTATGACAAACCGTAGTCAGGCGGTACGATTGCCTGCAGAAGTGCGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGCAATGAACGTATTTTGGCGCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGTT
CGTCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References