209001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2494411..2495056 Replicon chromosome
Accession NZ_CP078110
Organism Cronobacter sakazakii strain MOD1-H322

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3QTA3
Locus tag BTK77_RS11795 Protein ID WP_004388208.1
Coordinates 2494694..2495056 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6L3TU83
Locus tag BTK77_RS11790 Protein ID WP_004388209.1
Coordinates 2494411..2494707 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTK77_RS11780 (BTK77_011780) 2492065..2492913 - 849 WP_080320350.1 DNA-3-methyladenine glycosylase 2 -
BTK77_RS11785 (BTK77_011785) 2493049..2494401 + 1353 WP_080320349.1 molecular chaperone -
BTK77_RS11790 (BTK77_011790) 2494411..2494707 - 297 WP_004388209.1 XRE family transcriptional regulator Antitoxin
BTK77_RS11795 (BTK77_011795) 2494694..2495056 - 363 WP_004388208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTK77_RS11800 (BTK77_011800) 2495287..2496534 + 1248 WP_069682326.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
BTK77_RS11805 (BTK77_011805) 2496534..2499656 + 3123 WP_054624226.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14197.07 Da        Isoelectric Point: 8.0154

>T209001 WP_004388208.1 NZ_CP078110:c2495056-2494694 [Cronobacter sakazakii]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

>T209001 NZ_CP103783:c2219224-2218973 [Bacillus subtilis subsp. subtilis str. 168]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT209001 WP_004388209.1 NZ_CP078110:c2494707-2494411 [Cronobacter sakazakii]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT209001 NZ_CP103783:2219202-2219302 [Bacillus subtilis subsp. subtilis str. 168]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3QTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3TU83

References