Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1864824..1865389 Replicon chromosome
Accession NZ_CP078110
Organism Cronobacter sakazakii strain MOD1-H322

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BTK77_RS08750 Protein ID WP_080320795.1
Coordinates 1864824..1865102 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BTK77_RS08755 Protein ID WP_004388462.1
Coordinates 1865102..1865389 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTK77_RS08735 (BTK77_008735) 1859889..1861826 + 1938 WP_080320797.1 methyl-accepting chemotaxis protein -
BTK77_RS08740 (BTK77_008740) 1861934..1862920 + 987 WP_007888785.1 SDR family oxidoreductase -
BTK77_RS08745 (BTK77_008745) 1862922..1864526 - 1605 WP_080320796.1 alpha-amylase family protein -
BTK77_RS08750 (BTK77_008750) 1864824..1865102 + 279 WP_080320795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTK77_RS08755 (BTK77_008755) 1865102..1865389 + 288 WP_004388462.1 HigA family addiction module antitoxin Antitoxin
BTK77_RS08760 (BTK77_008760) 1865449..1867566 - 2118 WP_080320794.1 TonB-dependent receptor PqqU -
BTK77_RS08765 (BTK77_008765) 1867844..1868902 + 1059 WP_080320793.1 YncE family protein -
BTK77_RS08770 (BTK77_008770) 1868933..1869799 - 867 WP_080320792.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10569.06 Da        Isoelectric Point: 10.0888

>T208992 WP_080320795.1 NZ_CP078110:1864824-1865102 [Cronobacter sakazakii]
MIRSFRHKGLQRYFETGSTAGIHAPHARKISLRLAVLNQAIRPADVDLPGFFLHPLTGDRKGIWAVTVSGNWRITFEFRD
GDVFIVNYEDYH

Download         Length: 279 bp

>T208992 NZ_CP103771:4913382-4913693 [Salmonella enterica]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10428.03 Da        Isoelectric Point: 8.7791

>AT208992 WP_004388462.1 NZ_CP078110:1865102-1865389 [Cronobacter sakazakii]
MATMFNPPHPGRLVQESMEALGLSARALAKALDVAPSTVQRLLVGKSDVSPEMALRLSAVLGSSPHVWLGMQNEYDLFQA
RQSVDFSHLQRLQRA

Download         Length: 288 bp

>AT208992 NZ_CP103771:4913694-4913984 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References