208983

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 197985..198520 Replicon plasmid unnamed
Accession NZ_CP078095
Organism Enterococcus lactis strain JDM1

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag KVG00_RS13285 Protein ID WP_002314366.1
Coordinates 197985..198257 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag KVG00_RS13290 Protein ID WP_002297422.1
Coordinates 198257..198520 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVG00_RS13250 (KVG00_13250) 193001..193510 - 510 Protein_195 IS30 family transposase -
KVG00_RS13255 (KVG00_13255) 193465..194610 - 1146 WP_229205630.1 S8 family serine peptidase -
KVG00_RS13260 (KVG00_13260) 194622..195350 - 729 WP_156295078.1 S8 family serine peptidase -
KVG00_RS13265 (KVG00_13265) 195610..196158 - 549 WP_002292681.1 hypothetical protein -
KVG00_RS13270 (KVG00_13270) 196159..197016 - 858 WP_002292680.1 ParA family protein -
KVG00_RS13275 (KVG00_13275) 197302..197589 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
KVG00_RS13280 (KVG00_13280) 197579..197908 - 330 WP_002292678.1 AbrB family transcriptional regulator -
KVG00_RS13285 (KVG00_13285) 197985..198257 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
KVG00_RS13290 (KVG00_13290) 198257..198520 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KVG00_RS13295 (KVG00_13295) 198754..199662 + 909 Protein_204 IS982 family transposase -
KVG00_RS13300 (KVG00_13300) 199665..200840 - 1176 WP_156294920.1 MFS transporter -
KVG00_RS13305 (KVG00_13305) 200843..203092 - 2250 WP_002342422.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ClpL - 1..211593 211593
- flank IS/Tn - - 193001..193384 383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T208983 WP_002314366.1 NZ_CP078095:c198257-197985 [Enterococcus lactis]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T208983 NZ_CP103771:554273-554560 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTCCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT208983 WP_002297422.1 NZ_CP078095:c198520-198257 [Enterococcus lactis]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT208983 NZ_CP103771:554547-554849 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References