Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2442128..2442736 Replicon chromosome
Accession NZ_CP078069
Organism Comamonas sp. NLF-1-9

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KUD94_RS11730 Protein ID WP_218237382.1
Coordinates 2442128..2442409 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KUD94_RS11735 Protein ID WP_255568797.1
Coordinates 2442422..2442736 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUD94_RS11715 (KUD94_11715) 2437422..2438483 + 1062 WP_218237379.1 magnesium/cobalt transporter CorA -
KUD94_RS11720 (KUD94_11720) 2438523..2441477 + 2955 WP_218237380.1 excinuclease ABC subunit UvrA -
KUD94_RS11725 (KUD94_11725) 2441559..2442074 - 516 WP_218237381.1 DEAD/DEAH box helicase family protein -
KUD94_RS11730 (KUD94_11730) 2442128..2442409 + 282 WP_218237382.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUD94_RS11735 (KUD94_11735) 2442422..2442736 + 315 WP_255568797.1 HigA family addiction module antitoxin Antitoxin
KUD94_RS11740 (KUD94_11740) 2442757..2443095 - 339 WP_218237383.1 hypothetical protein -
KUD94_RS11745 (KUD94_11745) 2443180..2443335 - 156 WP_218237384.1 hypothetical protein -
KUD94_RS11750 (KUD94_11750) 2443540..2444778 - 1239 WP_218237385.1 5-demethoxyubiquinol-8 5-hydroxylase UbiM -
KUD94_RS11755 (KUD94_11755) 2445019..2446332 - 1314 WP_218237386.1 fumarylacetoacetase -
KUD94_RS11760 (KUD94_11760) 2446405..2447214 - 810 WP_218237387.1 cyclase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-75)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10956.44 Da        Isoelectric Point: 9.2057

>T208965 WP_218237382.1 NZ_CP078069:2442128-2442409 [Comamonas sp. NLF-1-9]
MIRSFADKETESLFRTGKSRKLPPDILRRAVLRLNQLEHATDIHELRFPPANRLEALHGDRSGQWSIRVNGQWRVCFRFV
DGDVFDVHITDYH

Download         Length: 282 bp

>T208965 NZ_CP103762:4620127-4620504 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11726.50 Da        Isoelectric Point: 7.3186

>AT208965 WP_255568797.1 NZ_CP078069:2442422-2442736 [Comamonas sp. NLF-1-9]
MKHTIERTSNGLPPIHPGEYIREALEDLGLTQAALAKLLGVSAMRISHLVREERPVTAEMALRLGRAFGQSPEYWLNLQA
GYDLKIAREQFKDSLREIRELATA

Download         Length: 315 bp

>AT208965 NZ_CP103762:4619669-4620037 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References