Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 530380..530995 Replicon chromosome
Accession NZ_CP078069
Organism Comamonas sp. NLF-1-9

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KUD94_RS02575 Protein ID WP_146911344.1
Coordinates 530714..530995 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KUD94_RS02570 Protein ID WP_146911346.1
Coordinates 530380..530688 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUD94_RS02520 (KUD94_02520) 525508..526158 + 651 WP_146911365.1 ATP phosphoribosyltransferase -
KUD94_RS14645 526265..526411 + 147 Protein_496 type II toxin-antitoxin system VapB family antitoxin -
KUD94_RS02530 (KUD94_02530) 526546..527865 + 1320 WP_218238336.1 histidinol dehydrogenase -
KUD94_RS02535 (KUD94_02535) 527853..527972 + 120 Protein_498 type II toxin-antitoxin system RelE/ParE family toxin -
KUD94_RS02540 (KUD94_02540) 528048..528293 + 246 WP_255569167.1 HigA family addiction module antitoxin -
KUD94_RS02545 (KUD94_02545) 528384..528680 - 297 Protein_500 PIN domain-containing protein -
KUD94_RS02550 (KUD94_02550) 528877..529248 + 372 WP_218238337.1 type II toxin-antitoxin system RelE/ParE family toxin -
KUD94_RS02555 (KUD94_02555) 529245..529565 + 321 WP_146911350.1 DNA-binding transcriptional regulator -
KUD94_RS02560 (KUD94_02560) 529645..529791 + 147 WP_146911348.1 type II toxin-antitoxin system MqsR family toxin -
KUD94_RS02565 (KUD94_02565) 529793..530212 + 420 WP_146911347.1 type II toxin-antitoxin system MqsA family antitoxin -
KUD94_RS02570 (KUD94_02570) 530380..530688 - 309 WP_146911346.1 HigA family addiction module antitoxin Antitoxin
KUD94_RS02575 (KUD94_02575) 530714..530995 - 282 WP_146911344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUD94_RS02580 (KUD94_02580) 531090..531479 - 390 WP_146911342.1 transcriptional regulator -
KUD94_RS02585 (KUD94_02585) 531680..532237 - 558 WP_146911340.1 hypothetical protein -
KUD94_RS02590 (KUD94_02590) 532516..533001 + 486 WP_218239162.1 pilin -
KUD94_RS02595 (KUD94_02595) 534044..534346 - 303 Protein_510 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
KUD94_RS02600 (KUD94_02600) 534343..534834 - 492 WP_218238338.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 526265..536757 10492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10695.22 Da        Isoelectric Point: 10.1076

>T208962 WP_146911344.1 NZ_CP078069:c530995-530714 [Comamonas sp. NLF-1-9]
MPIVSFRCPDTQRLFTSGKTRRFSSFQSVAERKLAQLDAAVTLDFLRSPPGNRLELLTGDRQGQHSIRINGQWRVCFVWT
DKGPMNVEIVDYH

Download         Length: 282 bp

>T208962 NZ_CP103762:4341364-4341621 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11267.03 Da        Isoelectric Point: 9.1116

>AT208962 WP_146911346.1 NZ_CP078069:c530688-530380 [Comamonas sp. NLF-1-9]
MVKNGMRPIHPGEILREDYLKPLQLSANALAGQLHVPASRINDIVLGRRGITADTALRLCRFFGGDARSWLNLQTAYDLR
VAELDGAVQQAVQTVHPMLHPT

Download         Length: 309 bp

>AT208962 NZ_CP103762:4341633-4342178 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References