Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 529645..530212 | Replicon | chromosome |
| Accession | NZ_CP078069 | ||
| Organism | Comamonas sp. NLF-1-9 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | - |
| Locus tag | KUD94_RS02560 | Protein ID | WP_146911348.1 |
| Coordinates | 529645..529791 (+) | Length | 49 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | - |
| Locus tag | KUD94_RS02565 | Protein ID | WP_146911347.1 |
| Coordinates | 529793..530212 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUD94_RS02520 (KUD94_02520) | 525508..526158 | + | 651 | WP_146911365.1 | ATP phosphoribosyltransferase | - |
| KUD94_RS14645 | 526265..526411 | + | 147 | Protein_496 | type II toxin-antitoxin system VapB family antitoxin | - |
| KUD94_RS02530 (KUD94_02530) | 526546..527865 | + | 1320 | WP_218238336.1 | histidinol dehydrogenase | - |
| KUD94_RS02535 (KUD94_02535) | 527853..527972 | + | 120 | Protein_498 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KUD94_RS02540 (KUD94_02540) | 528048..528293 | + | 246 | WP_255569167.1 | HigA family addiction module antitoxin | - |
| KUD94_RS02545 (KUD94_02545) | 528384..528680 | - | 297 | Protein_500 | PIN domain-containing protein | - |
| KUD94_RS02550 (KUD94_02550) | 528877..529248 | + | 372 | WP_218238337.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KUD94_RS02555 (KUD94_02555) | 529245..529565 | + | 321 | WP_146911350.1 | DNA-binding transcriptional regulator | - |
| KUD94_RS02560 (KUD94_02560) | 529645..529791 | + | 147 | WP_146911348.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| KUD94_RS02565 (KUD94_02565) | 529793..530212 | + | 420 | WP_146911347.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| KUD94_RS02570 (KUD94_02570) | 530380..530688 | - | 309 | WP_146911346.1 | HigA family addiction module antitoxin | - |
| KUD94_RS02575 (KUD94_02575) | 530714..530995 | - | 282 | WP_146911344.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KUD94_RS02580 (KUD94_02580) | 531090..531479 | - | 390 | WP_146911342.1 | transcriptional regulator | - |
| KUD94_RS02585 (KUD94_02585) | 531680..532237 | - | 558 | WP_146911340.1 | hypothetical protein | - |
| KUD94_RS02590 (KUD94_02590) | 532516..533001 | + | 486 | WP_218239162.1 | pilin | - |
| KUD94_RS02595 (KUD94_02595) | 534044..534346 | - | 303 | Protein_510 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| KUD94_RS02600 (KUD94_02600) | 534343..534834 | - | 492 | WP_218238338.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 526265..536757 | 10492 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 49 a.a. Molecular weight: 5536.42 Da Isoelectric Point: 7.2401
>T208961 WP_146911348.1 NZ_CP078069:529645-529791 [Comamonas sp. NLF-1-9]
MFYKSMTTHADHTLWQDVYHAPCPNGCMAYIKVTFRADGAVVLQFKEL
MFYKSMTTHADHTLWQDVYHAPCPNGCMAYIKVTFRADGAVVLQFKEL
Download Length: 147 bp
>T208961 NZ_CP103762:c3949244-3948846 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15038.12 Da Isoelectric Point: 8.1485
>AT208961 WP_146911347.1 NZ_CP078069:529793-530212 [Comamonas sp. NLF-1-9]
MTPDAKNRYCLQCDDGTALVHTTKDVHGEIMGVPYSVKGVTGWHCPACGEIEYDLQGDSAARMSAAVEAAGQEARQRQAL
ALRAARKKLGLSQAEAGRLFGGGVSAFSEYERGKTQPHKSTVLLMRLLDKHPNLLAEVR
MTPDAKNRYCLQCDDGTALVHTTKDVHGEIMGVPYSVKGVTGWHCPACGEIEYDLQGDSAARMSAAVEAAGQEARQRQAL
ALRAARKKLGLSQAEAGRLFGGGVSAFSEYERGKTQPHKSTVLLMRLLDKHPNLLAEVR
Download Length: 420 bp
>AT208961 NZ_CP103762:c3949540-3949247 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|