208916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 81194..81845 Replicon plasmid pAV_175-2
Accession NZ_CP078028
Organism Acinetobacter variabilis strain AV_175

Toxin (Protein)


Gene name higB Uniprot ID N9NM16
Locus tag EGK58_RS15865 Protein ID WP_004668307.1
Coordinates 81194..81550 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGK58_RS15870 Protein ID WP_001140620.1
Coordinates 81543..81845 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGK58_RS15830 (EGK58_015830) 76726..77625 + 900 WP_125279792.1 cation diffusion facilitator family transporter -
EGK58_RS15835 (EGK58_015835) 77829..78011 + 183 WP_004897244.1 hypothetical protein -
EGK58_RS15840 (EGK58_015840) 78237..78446 - 210 WP_228127370.1 hypothetical protein -
EGK58_RS15845 (EGK58_015845) 78593..79297 + 705 WP_219014821.1 IS6-like element IS1006 family transposase -
EGK58_RS15850 (EGK58_015850) 79351..79536 - 186 Protein_80 helix-turn-helix domain-containing protein -
EGK58_RS15855 (EGK58_015855) 79724..80155 - 432 WP_005108698.1 MarR family transcriptional regulator -
EGK58_RS15860 (EGK58_015860) 80162..80590 - 429 WP_005108699.1 organic hydroperoxide resistance protein -
EGK58_RS15865 (EGK58_015865) 81194..81550 + 357 WP_004668307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGK58_RS15870 (EGK58_015870) 81543..81845 + 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
EGK58_RS15875 (EGK58_015875) 81887..82048 - 162 Protein_85 IS6 family transposase -
EGK58_RS15880 (EGK58_015880) 82142..82534 - 393 WP_000550240.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
EGK58_RS15885 (EGK58_015885) 82624..83904 + 1281 WP_004695728.1 cation transporter -
EGK58_RS15890 (EGK58_015890) 83968..84648 + 681 WP_228737550.1 IS6 family transposase -
EGK58_RS15895 (EGK58_015895) 84616..85548 - 933 WP_000743268.1 IS5-like element IS17 family transposase -
EGK58_RS15900 (EGK58_015900) 85587..86222 + 636 Protein_90 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..196965 196965
- inside IScluster/Tn - - 78593..91265 12672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13610.64 Da        Isoelectric Point: 7.1651

>T208916 WP_004668307.1 NZ_CP078028:81194-81550 [Acinetobacter variabilis]
MWTVITTDLFNQWLEQQDEPTQEKVLAALVVLQQQGPSLGRPLVDTVYESKFTNMKELRVQHRGRPLRAFFAFDPLRQAI
VLCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

>T208916 NZ_CP103756:62658-62807 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT208916 WP_001140620.1 NZ_CP078028:81543-81845 [Acinetobacter variabilis]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT208916 NZ_CP103756:c62614-62553 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9NM16

Antitoxin

Source ID Structure

References