Detailed information of TA system TA208901

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 33540..33754
• Replicon: plasmid pSY-1-optrA
• Accession: NZ_CP078016
• Organism: Enterococcus faecalis strain SY-1

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: KUO14_RS14275
• Protein ID: WP_002360667.1
• Coordinates: 33540..33650 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	33690..33754 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUO14_RS14235	29562..29903	-	342	WP_002362432.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KUO14_RS14240	29903..30133	-	231	WP_002362431.1	hypothetical protein	-
KUO14_RS14245	30337..30957	+	621	WP_013438829.1	recombinase family protein	-
KUO14_RS14250	30974..31258	+	285	WP_002394798.1	hypothetical protein	-
KUO14_RS14255	31260..31493	+	234	WP_002394799.1	hypothetical protein	-
KUO14_RS14260	31653..31907	-	255	WP_002394800.1	hypothetical protein	-
KUO14_RS14265	32024..32692	-	669	WP_002403283.1	CPBP family intramembrane metalloprotease	-
KUO14_RS14270	32728..33045	-	318	WP_002394802.1	heavy metal-binding domain-containing protein	-
KUO14_RS14275	33540..33650	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	33690..33754	-	65	-	-	Antitoxin
KUO14_RS14280	33890..34186	+	297	WP_002403282.1	hypothetical protein	-
KUO14_RS14285	34345..34686	-	342	WP_002382053.1	hypothetical protein	-
KUO14_RS14290	34690..35592	-	903	WP_002382055.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(B) / aph(3')-III / dfrG / fexA / optrA / erm(A)	-	1..35987	35987

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T208901 WP_002360667.1 NZ_CP078016:33540-33650 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T208901 NZ_CP103755:1934298-1934552 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 65 bp

>AT208901 NZ_CP078016:c33754-33690 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Structures

Antitoxin