Detailed information of TA system TA208894

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2649215..2649439
• Replicon: chromosome
• Accession: NZ_CP078015
• Organism: Enterococcus faecalis strain SY-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KUO14_RS12885
• Protein ID: WP_224561205.1
• Coordinates: 2649338..2649439 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2649215..2649393 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUO14_RS12860	2644862..2645815	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
KUO14_RS12865	2645854..2646609	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KUO14_RS12870	2646606..2647571	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
KUO14_RS12875	2647568..2648515	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
KUO14_RS12880	2648700..2649152	+	453	WP_002378807.1	YueI family protein	-
-	2649215..2649393	+	179	-	-	Antitoxin
KUO14_RS12885	2649338..2649439	-	102	WP_224561205.1	putative holin-like toxin	Toxin
KUO14_RS12890	2649630..2651900	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KUO14_RS12895	2652071..2652577	+	507	WP_002378810.1	cysteine hydrolase family protein	-
KUO14_RS12900	2652767..2653663	+	897	WP_002365354.1	YitT family protein	-
KUO14_RS12905	2653714..2654112	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T208894 WP_224561205.1 NZ_CP078015:c2649439-2649338 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T208894 NZ_CP103755:186715-186822 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT208894 NZ_CP078015:2649215-2649393 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin