208879

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5575327..5575922 Replicon chromosome
Accession NZ_CP078009
Organism Pseudomonas aeruginosa strain FAHZU31

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag KUU74_RS26100 Protein ID WP_003113526.1
Coordinates 5575644..5575922 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KUU74_RS26095 Protein ID WP_003113527.1
Coordinates 5575327..5575632 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU74_RS26075 (KUU74_26070) 5571403..5571660 + 258 WP_010793759.1 ATP-binding protein -
KUU74_RS26080 (KUU74_26075) 5572036..5572899 - 864 WP_010793758.1 integrase domain-containing protein -
KUU74_RS26085 (KUU74_26080) 5573501..5574643 - 1143 WP_010793757.1 STY4528 family pathogenicity island replication protein -
KUU74_RS26095 (KUU74_26090) 5575327..5575632 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
KUU74_RS26100 (KUU74_26095) 5575644..5575922 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU74_RS31535 5575975..5576103 - 129 Protein_5178 integrase -
KUU74_RS26105 (KUU74_26100) 5576251..5578479 + 2229 WP_003099265.1 TonB-dependent receptor -
KUU74_RS26110 (KUU74_26105) 5578549..5579196 - 648 WP_003095021.1 carbonate dehydratase -
KUU74_RS26115 (KUU74_26110) 5579258..5580496 - 1239 WP_010793756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T208879 WP_003113526.1 NZ_CP078009:c5575922-5575644 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T208879 NZ_CP103747:37694-37843 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT208879 WP_003113527.1 NZ_CP078009:c5575632-5575327 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT208879 NZ_CP103747:c37650-37589 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References