208850

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5711123..5711718 Replicon chromosome
Accession NZ_CP078002
Organism Pseudomonas aeruginosa strain QZPH21

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag KUU68_RS26710 Protein ID WP_003113526.1
Coordinates 5711440..5711718 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KUU68_RS26705 Protein ID WP_003099268.1
Coordinates 5711123..5711428 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU68_RS26675 (KUU68_26670) 5706169..5706603 - 435 WP_009875803.1 hypothetical protein -
KUU68_RS26680 (KUU68_26675) 5707119..5707409 - 291 WP_152959653.1 DUF5447 family protein -
KUU68_RS26685 (KUU68_26680) 5707585..5707857 - 273 WP_058175553.1 hypothetical protein -
KUU68_RS26690 (KUU68_26685) 5708304..5708639 + 336 WP_058175552.1 hypothetical protein -
KUU68_RS26695 (KUU68_26690) 5708642..5709343 - 702 WP_152959654.1 retron Ec48 family effector membrane protein -
KUU68_RS26700 (KUU68_26695) 5709330..5710505 - 1176 WP_071557852.1 reverse transcriptase family protein -
KUU68_RS26705 (KUU68_26700) 5711123..5711428 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
KUU68_RS26710 (KUU68_26705) 5711440..5711718 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU68_RS32010 5711771..5711899 - 129 Protein_5292 integrase -
KUU68_RS26715 (KUU68_26710) 5712047..5714275 + 2229 WP_003099265.1 TonB-dependent receptor -
KUU68_RS26720 (KUU68_26715) 5714345..5714992 - 648 WP_003095021.1 carbonate dehydratase -
KUU68_RS26725 (KUU68_26720) 5715054..5716292 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T208850 WP_003113526.1 NZ_CP078002:c5711718-5711440 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T208850 NZ_CP103743:48648-48782 [Escherichia coli O25b:H4-ST131]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT208850 WP_003099268.1 NZ_CP078002:c5711428-5711123 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT208850 NZ_CP103743:c48603-48543 [Escherichia coli O25b:H4-ST131]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References