Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5922014..5922609 Replicon chromosome
Accession NZ_CP077999
Organism Pseudomonas aeruginosa strain SRRSH1120

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag KUU71_RS27500 Protein ID WP_003113526.1
Coordinates 5922331..5922609 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KUU71_RS27495 Protein ID WP_003099268.1
Coordinates 5922014..5922319 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU71_RS27465 (KUU71_27460) 5917060..5917494 - 435 WP_009875803.1 hypothetical protein -
KUU71_RS27470 (KUU71_27465) 5918010..5918300 - 291 WP_152959653.1 DUF5447 family protein -
KUU71_RS27475 (KUU71_27470) 5918476..5918748 - 273 WP_058175553.1 hypothetical protein -
KUU71_RS27480 (KUU71_27475) 5919195..5919530 + 336 WP_058175552.1 hypothetical protein -
KUU71_RS27485 (KUU71_27480) 5919533..5920234 - 702 WP_152959654.1 retron Ec48 family effector membrane protein -
KUU71_RS27490 (KUU71_27485) 5920221..5921396 - 1176 WP_071557852.1 reverse transcriptase family protein -
KUU71_RS27495 (KUU71_27490) 5922014..5922319 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
KUU71_RS27500 (KUU71_27495) 5922331..5922609 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU71_RS33425 5922662..5922790 - 129 Protein_5456 integrase -
KUU71_RS27505 (KUU71_27500) 5922938..5925166 + 2229 WP_003099265.1 TonB-dependent receptor -
KUU71_RS27510 (KUU71_27505) 5925236..5925883 - 648 WP_003095021.1 carbonate dehydratase -
KUU71_RS27515 (KUU71_27510) 5925945..5927183 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T208841 WP_003113526.1 NZ_CP077999:c5922609-5922331 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T208841 NZ_CP103742:2666655-2666762 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT208841 WP_003099268.1 NZ_CP077999:c5922319-5922014 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT208841 NZ_CP103742:c2666598-2666543 [Escherichia coli O25b:H4-ST131]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References