Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5914485..5915080 Replicon chromosome
Accession NZ_CP077994
Organism Pseudomonas aeruginosa strain SRRSH2790

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag KUU72_RS27625 Protein ID WP_003113526.1
Coordinates 5914802..5915080 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KUU72_RS27620 Protein ID WP_003099268.1
Coordinates 5914485..5914790 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU72_RS27590 (KUU72_27585) 5909531..5909965 - 435 WP_009875803.1 hypothetical protein -
KUU72_RS27595 (KUU72_27590) 5910481..5910771 - 291 WP_152959653.1 DUF5447 family protein -
KUU72_RS27600 (KUU72_27595) 5910947..5911219 - 273 WP_058175553.1 hypothetical protein -
KUU72_RS27605 (KUU72_27600) 5911666..5912001 + 336 WP_058175552.1 hypothetical protein -
KUU72_RS27610 (KUU72_27605) 5912004..5912705 - 702 WP_152959654.1 retron Ec48 family effector membrane protein -
KUU72_RS27615 (KUU72_27610) 5912692..5913867 - 1176 WP_071557852.1 reverse transcriptase family protein -
KUU72_RS27620 (KUU72_27615) 5914485..5914790 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
KUU72_RS27625 (KUU72_27620) 5914802..5915080 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU72_RS33325 5915133..5915261 - 129 Protein_5477 integrase -
KUU72_RS27630 (KUU72_27625) 5915409..5917637 + 2229 WP_003099265.1 TonB-dependent receptor -
KUU72_RS27635 (KUU72_27630) 5917707..5918354 - 648 WP_003095021.1 carbonate dehydratase -
KUU72_RS27640 (KUU72_27635) 5918416..5919654 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T208826 WP_003113526.1 NZ_CP077994:c5915080-5914802 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T208826 NZ_CP103740:63540-63674 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT208826 WP_003099268.1 NZ_CP077994:c5914790-5914485 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT208826 NZ_CP103740:c63495-63435 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References