Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1299793..1300415 Replicon chromosome
Accession NZ_CP077988
Organism Pseudomonas aeruginosa strain ZPPH1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KUU79_RS06255 Protein ID WP_023910260.1
Coordinates 1299793..1300107 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KUU79_RS06260 Protein ID WP_023910258.1
Coordinates 1300110..1300415 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUU79_RS06230 (KUU79_06230) 1295348..1296304 + 957 WP_223716503.1 site-specific integrase -
KUU79_RS06235 (KUU79_06235) 1296373..1296684 + 312 WP_031631670.1 outer membrane protein assembly factor BamE -
KUU79_RS06240 (KUU79_06240) 1296816..1297466 + 651 WP_058172679.1 BRCT domain-containing protein -
KUU79_RS06245 (KUU79_06245) 1297750..1298319 + 570 WP_073625159.1 hypothetical protein -
KUU79_RS06250 (KUU79_06250) 1298306..1299211 + 906 WP_128682883.1 hypothetical protein -
KUU79_RS06255 (KUU79_06255) 1299793..1300107 + 315 WP_023910260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUU79_RS06260 (KUU79_06260) 1300110..1300415 + 306 WP_023910258.1 helix-turn-helix domain-containing protein Antitoxin
KUU79_RS06265 (KUU79_06265) 1300476..1300775 - 300 WP_222821501.1 hypothetical protein -
KUU79_RS32210 1301269..1301677 - 409 Protein_1244 hypothetical protein -
KUU79_RS06270 (KUU79_06270) 1301674..1303827 - 2154 WP_034074643.1 DNA cytosine methyltransferase -
KUU79_RS06275 (KUU79_06275) 1303824..1304369 - 546 WP_031632204.1 phosphohydrolase -
KUU79_RS06280 (KUU79_06280) 1304378..1305112 - 735 WP_031630972.1 hypothetical protein -
KUU79_RS32215 1305188..1305319 - 132 WP_255253799.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1292599..1340994 48395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11776.54 Da        Isoelectric Point: 9.4385

>T208812 WP_023910260.1 NZ_CP077988:1299793-1300107 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR

Download         Length: 315 bp

>T208812 NZ_CP103739:c2162317-2162210 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11316.84 Da        Isoelectric Point: 7.2077

>AT208812 WP_023910258.1 NZ_CP077988:1300110-1300415 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES

Download         Length: 306 bp

>AT208812 NZ_CP103739:2162364-2162430 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References