Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
Location | 1299793..1300415 | Replicon | chromosome |
Accession | NZ_CP077988 | ||
Organism | Pseudomonas aeruginosa strain ZPPH1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | KUU79_RS06255 | Protein ID | WP_023910260.1 |
Coordinates | 1299793..1300107 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | KUU79_RS06260 | Protein ID | WP_023910258.1 |
Coordinates | 1300110..1300415 (+) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KUU79_RS06230 (KUU79_06230) | 1295348..1296304 | + | 957 | WP_223716503.1 | site-specific integrase | - |
KUU79_RS06235 (KUU79_06235) | 1296373..1296684 | + | 312 | WP_031631670.1 | outer membrane protein assembly factor BamE | - |
KUU79_RS06240 (KUU79_06240) | 1296816..1297466 | + | 651 | WP_058172679.1 | BRCT domain-containing protein | - |
KUU79_RS06245 (KUU79_06245) | 1297750..1298319 | + | 570 | WP_073625159.1 | hypothetical protein | - |
KUU79_RS06250 (KUU79_06250) | 1298306..1299211 | + | 906 | WP_128682883.1 | hypothetical protein | - |
KUU79_RS06255 (KUU79_06255) | 1299793..1300107 | + | 315 | WP_023910260.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KUU79_RS06260 (KUU79_06260) | 1300110..1300415 | + | 306 | WP_023910258.1 | helix-turn-helix domain-containing protein | Antitoxin |
KUU79_RS06265 (KUU79_06265) | 1300476..1300775 | - | 300 | WP_222821501.1 | hypothetical protein | - |
KUU79_RS32210 | 1301269..1301677 | - | 409 | Protein_1244 | hypothetical protein | - |
KUU79_RS06270 (KUU79_06270) | 1301674..1303827 | - | 2154 | WP_034074643.1 | DNA cytosine methyltransferase | - |
KUU79_RS06275 (KUU79_06275) | 1303824..1304369 | - | 546 | WP_031632204.1 | phosphohydrolase | - |
KUU79_RS06280 (KUU79_06280) | 1304378..1305112 | - | 735 | WP_031630972.1 | hypothetical protein | - |
KUU79_RS32215 | 1305188..1305319 | - | 132 | WP_255253799.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1292599..1340994 | 48395 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11776.54 Da Isoelectric Point: 9.4385
>T208812 WP_023910260.1 NZ_CP077988:1299793-1300107 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR
Download Length: 315 bp
>T208812 NZ_CP103739:c2162317-2162210 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11316.84 Da Isoelectric Point: 7.2077
>AT208812 WP_023910258.1 NZ_CP077988:1300110-1300415 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES
Download Length: 306 bp
>AT208812 NZ_CP103739:2162364-2162430 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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