Detailed information of TA system TA208772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3080442..3081135
• Replicon: chromosome
• Accession: NZ_CP077969
• Organism: Escherichia coli strain JM83

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: KTJ86_RS14955
• Protein ID: WP_000415584.1
• Coordinates: 3080839..3081135 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: KTJ86_RS14950
• Protein ID: WP_000650107.1
• Coordinates: 3080442..3080837 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTJ86_RS14940 (3076306)	3076306..3078564	-	2259	WP_001281881.1	DNA topoisomerase IV subunit A	-
KTJ86_RS14945 (3078702)	3078702..3080309	-	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
KTJ86_RS14950 (3080442)	3080442..3080837	-	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
KTJ86_RS14955 (3080839)	3080839..3081135	-	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
KTJ86_RS14960 (3081340)	3081340..3081822	-	483	WP_000183505.1	GyrI-like domain-containing protein	-
KTJ86_RS14965 (3081875)	3081875..3082267	-	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
KTJ86_RS14970 (3082419)	3082419..3083078	+	660	WP_001221495.1	quorum sensing response regulator transcription factor QseB	-
KTJ86_RS14975 (3083075)	3083075..3084424	+	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
KTJ86_RS14980 (3084470)	3084470..3084802	-	333	WP_000917684.1	DUF2645 family protein	-
KTJ86_RS14985 (3085121)	3085121..3085702	+	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
KTJ86_RS14990 (3085733)	3085733..3086047	+	315	WP_000958598.1	putative quinol monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T208772 WP_000415584.1 NZ_CP077969:c3081135-3080839 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T208772 NZ_CP103727:c4513827-4513294 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT208772 WP_000650107.1 NZ_CP077969:c3080837-3080442 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT208772 NZ_CP103727:c4514104-4513838 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65