Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3080442..3081135 Replicon chromosome
Accession NZ_CP077969
Organism Escherichia coli strain JM83

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KTJ86_RS14955 Protein ID WP_000415584.1
Coordinates 3080839..3081135 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KTJ86_RS14950 Protein ID WP_000650107.1
Coordinates 3080442..3080837 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ86_RS14940 (3076306) 3076306..3078564 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
KTJ86_RS14945 (3078702) 3078702..3080309 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KTJ86_RS14950 (3080442) 3080442..3080837 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KTJ86_RS14955 (3080839) 3080839..3081135 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KTJ86_RS14960 (3081340) 3081340..3081822 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KTJ86_RS14965 (3081875) 3081875..3082267 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KTJ86_RS14970 (3082419) 3082419..3083078 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
KTJ86_RS14975 (3083075) 3083075..3084424 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KTJ86_RS14980 (3084470) 3084470..3084802 - 333 WP_000917684.1 DUF2645 family protein -
KTJ86_RS14985 (3085121) 3085121..3085702 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KTJ86_RS14990 (3085733) 3085733..3086047 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T208772 WP_000415584.1 NZ_CP077969:c3081135-3080839 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T208772 NZ_CP103727:c4513827-4513294 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT208772 WP_000650107.1 NZ_CP077969:c3080837-3080442 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT208772 NZ_CP103727:c4514104-4513838 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References