Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2587368..2587552 Replicon chromosome
Accession NZ_CP077936
Organism Staphylococcus aureus strain 319

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KU496_RS13095 Protein ID WP_000482647.1
Coordinates 2587445..2587552 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2587368..2587428 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU496_RS13080 2582878..2583045 - 168 Protein_2543 hypothetical protein -
KU496_RS13085 2583276..2585009 - 1734 WP_000486505.1 ABC transporter ATP-binding protein -
KU496_RS13090 2585034..2586797 - 1764 WP_001064829.1 ABC transporter ATP-binding protein -
- 2587368..2587428 + 61 - - Antitoxin
KU496_RS13095 2587445..2587552 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
KU496_RS13100 2587686..2588072 - 387 WP_000779351.1 flippase GtxA -
KU496_RS13105 2588340..2589482 + 1143 WP_001176855.1 glycerate kinase -
KU496_RS13110 2589542..2590201 + 660 WP_000831298.1 membrane protein -
KU496_RS13115 2590383..2591594 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
KU496_RS13120 2591717..2592190 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T208723 WP_000482647.1 NZ_CP077936:c2587552-2587445 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208723 NZ_CP103718:220768-220875 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT208723 NZ_CP077936:2587368-2587428 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References