208722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2562066..2562583 Replicon chromosome
Accession NZ_CP077936
Organism Staphylococcus aureus strain 319

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag KU496_RS12960 Protein ID WP_000251928.1
Coordinates 2562066..2562332 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag KU496_RS12965 Protein ID WP_000584497.1
Coordinates 2562332..2562583 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU496_RS12935 (2557274) 2557274..2557810 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
KU496_RS12940 (2558278) 2558278..2559102 - 825 WP_000594640.1 formate/nitrite transporter family protein -
KU496_RS12945 (2559305) 2559305..2559487 - 183 WP_000079140.1 hypothetical protein -
KU496_RS12950 (2559573) 2559573..2560040 - 468 WP_000153340.1 SRPBCC domain-containing protein -
KU496_RS12955 (2560226) 2560226..2561773 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU496_RS12960 (2562066) 2562066..2562332 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
KU496_RS12965 (2562332) 2562332..2562583 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU496_RS12970 (2562747) 2562747..2562847 - 101 Protein_2521 hypothetical protein -
KU496_RS12975 (2562854) 2562854..2563453 - 600 WP_000162804.1 DsbA family protein -
KU496_RS12980 (2563472) 2563472..2563834 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU496_RS12985 (2564089) 2564089..2565339 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
KU496_RS12990 (2565436) 2565436..2566167 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
KU496_RS12995 (2566164) 2566164..2566883 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T208722 WP_000251928.1 NZ_CP077936:c2562332-2562066 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208722 NZ_CP103716:13166-13417 [Klebsiella pneumoniae]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT208722 WP_000584497.1 NZ_CP077936:c2562583-2562332 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT208722 NZ_CP103716:13404-13631 [Klebsiella pneumoniae]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References