Detailed information of TA system TA208716

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2109638..2109937
• Replicon: chromosome
• Accession: NZ_CP077936
• Organism: Staphylococcus aureus strain 319

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU496_RS10510
• Protein ID: WP_011447039.1
• Coordinates: 2109761..2109937 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2109638..2109695 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU496_RS10470	2105017..2105277	+	261	WP_001791826.1	hypothetical protein	-
KU496_RS10475	2105330..2105680	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU496_RS10480	2106365..2106814	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU496_RS10485	2106909..2107244	-	336	Protein_2038	SH3 domain-containing protein	-
KU496_RS10490	2107846..2108337	-	492	WP_000920041.1	staphylokinase	-
KU496_RS10495	2108528..2109283	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU496_RS10500	2109295..2109549	-	255	WP_000611512.1	phage holin	-
KU496_RS10505	2109601..2109708	+	108	WP_031790389.1	hypothetical protein	-
-	2109630..2109769	+	140	NuclAT_0	-	-
-	2109630..2109769	+	140	NuclAT_0	-	-
-	2109630..2109769	+	140	NuclAT_0	-	-
-	2109630..2109769	+	140	NuclAT_0	-	-
-	2109638..2109695	+	58	-	-	Antitoxin
KU496_RS10510	2109761..2109937	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU496_RS10515	2110087..2110383	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU496_RS10520	2110441..2110728	-	288	WP_001040261.1	hypothetical protein	-
KU496_RS10525	2110775..2110927	-	153	WP_001153681.1	hypothetical protein	-
KU496_RS10530	2110917..2114702	-	3786	WP_225798537.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / tsst-1 / groEL / hld	2099556..2182517	82961

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208716 WP_011447039.1 NZ_CP077936:c2109937-2109761 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208716 NZ_CP103714:c3833140-3832823 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208716 NZ_CP077936:2109638-2109695 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• PDB: 7NS1

Antitoxin