Detailed information of TA system TA020871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 458249..458955
• Replicon: chromosome
• Accession: NC_004556
• Organism: Xylella fastidiosa Temecula1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q87EE2
• Locus tag: PD_RS01945
• Protein ID: WP_004090696.1
• Coordinates: 458249..458551 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q87EE1
• Locus tag: PD_RS01950
• Protein ID: WP_004090697.1
• Coordinates: 458554..458955 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PD_RS01910	454017..454736	-	720	Protein_349	phage tail protein	-
PD_RS01915	454636..455607	-	972	WP_011097609.1	hypothetical protein	-
PD_RS01920	455615..456172	-	558	WP_011097610.1	phage tail protein I	-
PD_RS01925	456165..457058	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
PD_RS01930	457058..457396	-	339	WP_004090694.1	GPW/gp25 family protein	-
PD_RS01935	457594..457875	+	282	WP_004090695.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PD_RS01940	457886..458161	+	276	WP_004085172.1	HigA family addiction module antidote protein	-
PD_RS01945	458249..458551	+	303	WP_004090696.1	type II toxin-antitoxin system MqsR family toxin	Toxin
PD_RS01950	458554..458955	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PD_RS01955	459024..459611	-	588	WP_011097612.1	phage baseplate assembly protein V	-
PD_RS01960	459608..460150	-	543	WP_011097613.1	hypothetical protein	-
PD_RS01965	460126..460647	-	522	WP_011097614.1	hypothetical protein	-
PD_RS01970	460644..460967	-	324	WP_011097935.1	hypothetical protein	-
PD_RS01975	460967..461227	-	261	WP_011097616.1	hypothetical protein	-
PD_RS01980	461245..463119	-	1875	WP_011097617.1	phage major capsid protein	-
PD_RS01985	463116..463748	-	633	WP_011097618.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	446192..469025	22833

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10948.71 Da
• Isoelectric Point: 8.0251

>T20871 WP_004090696.1 NC_004556:458249-458551 [Xylella fastidiosa Temecula1]
MEKGTSHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCTVVLALTSADFYKSMTTYADHTVFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T20871 NC_004556:458249-458551 [Xylella fastidiosa Temecula1]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14944.02 Da
• Isoelectric Point: 7.1650

>AT20871 WP_004090697.1 NC_004556:458554-458955 [Xylella fastidiosa Temecula1]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNSAYVDPGYITKVRRK
LDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSS

Nucleotide

• Length: 402 bp

>AT20871 NC_004556:458554-458955 [Xylella fastidiosa Temecula1]
ATGAGATGTCCATGCTGCGGCGCGGCAGAACTGATCCACGACACGCGCGACATGCTTTACACCTACAAGAGCGAAACTAC
TAGTATCCCAACGGTGACCGGCGACTTCTGCCCGGCTTGTGGCGAAGTCGTCTTGGACCGTGAACATGGTGATCGTTACA
GCGAATTGGTCGGCTTGTTCCAACGTCAGGTGAATTCGGCCTACGTCGATCCTGGTTACATTACCAAGGTACGCCGGAAG
CTTGATCTCGACCAGCGGCAAGCTGCCGAACTGTTCGGTGGTGGTGTTAATGCTTTCTCACGTTACGAGAACGGTAAAAC
CAAGCCGCCGCTGTCTTTGGTTAAGTTATTCAAGCTTCTGGATCGCCACCCCGATTTGCTCAACGAAGTGAAGAGTTCCT
AA

Structures

Toxin

• AlphaFold DB: Q87EE2

Antitoxin

• AlphaFold DB: Q87EE1