Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1569136..1569559 | Replicon | chromosome |
| Accession | NZ_CP077936 | ||
| Organism | Staphylococcus aureus strain 319 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A6B5KJM6 |
| Locus tag | KU496_RS07480 | Protein ID | WP_001065110.1 |
| Coordinates | 1569308..1569559 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0E1X568 |
| Locus tag | KU496_RS07475 | Protein ID | WP_000028425.1 |
| Coordinates | 1569136..1569318 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU496_RS07435 (1564529) | 1564529..1564819 | - | 291 | WP_000665205.1 | VRR-NUC domain-containing protein | - |
| KU496_RS07440 (1564953) | 1564953..1565057 | + | 105 | WP_015978074.1 | hypothetical protein | - |
| KU496_RS07445 (1565160) | 1565160..1567607 | - | 2448 | WP_000884879.1 | virulence-associated E family protein | - |
| KU496_RS07450 (1567660) | 1567660..1567860 | - | 201 | WP_000265258.1 | DUF1514 family protein | - |
| KU496_RS07455 (1567928) | 1567928..1568080 | - | 153 | WP_000595237.1 | transcriptional activator RinB | - |
| KU496_RS07460 (1568073) | 1568073..1568309 | - | 237 | WP_000483477.1 | hypothetical protein | - |
| KU496_RS07465 (1568334) | 1568334..1568570 | - | 237 | WP_000195806.1 | DUF1381 domain-containing protein | - |
| KU496_RS07470 (1568607) | 1568607..1569143 | - | 537 | WP_000185703.1 | dUTPase | - |
| KU496_RS07475 (1569136) | 1569136..1569318 | - | 183 | WP_000028425.1 | hypothetical protein | Antitoxin |
| KU496_RS07480 (1569308) | 1569308..1569559 | - | 252 | WP_001065110.1 | DUF1024 family protein | Toxin |
| KU496_RS07485 (1569574) | 1569574..1569816 | - | 243 | WP_000132193.1 | SAV1978 family virulence-associated passenger protein | - |
| KU496_RS07490 (1569831) | 1569831..1570031 | - | 201 | WP_000235324.1 | hypothetical protein | - |
| KU496_RS07495 (1570034) | 1570034..1570291 | - | 258 | WP_000022730.1 | DUF3310 domain-containing protein | - |
| KU496_RS07500 (1570291) | 1570291..1570692 | - | 402 | WP_000113974.1 | PVL family protein | - |
| KU496_RS07505 (1570692) | 1570692..1570877 | - | 186 | WP_001164629.1 | DUF3113 family protein | - |
| KU496_RS07510 (1570890) | 1570890..1572842 | - | 1953 | WP_225798516.1 | DNA polymerase | - |
| KU496_RS07515 (1572910) | 1572910..1573467 | - | 558 | WP_000645048.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1535650..1599478 | 63828 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9405.32 Da Isoelectric Point: 3.8051
>T208709 WP_001065110.1 NZ_CP077936:c1569559-1569308 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T208709 NZ_CP103712:c68737-68357 [Escherichia coli O25b:H4-ST131]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 61 a.a. Molecular weight: 6781.65 Da Isoelectric Point: 4.4421
>AT208709 WP_000028425.1 NZ_CP077936:c1569318-1569136 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND
Download Length: 183 bp
>AT208709 NZ_CP103712:c68958-68737 [Escherichia coli O25b:H4-ST131]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6B5KJM6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1X568 |