Detailed information of TA system TA208703

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 13513..13792
• Replicon: plasmid unnamed2
• Accession: NZ_CP077935
• Organism: Staphylococcus aureus strain 359

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU512_RS13285
• Protein ID: WP_001802298.1
• Coordinates: 13513..13617 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	13613..13792 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU512_RS13255 (KU512_13245)	8897..9679	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
KU512_RS13260 (KU512_13250)	9747..10604	+	858	WP_000370924.1	HAD family hydrolase	-
KU512_RS13265	10836..11020	-	185	Protein_8	exotoxin	-
KU512_RS13270 (KU512_13255)	11309..11401	-	93	WP_001790138.1	hypothetical protein	-
KU512_RS13275 (KU512_13260)	11690..12826	+	1137	WP_000115562.1	SAP domain-containing protein	-
KU512_RS13280 (KU512_13265)	12869..13352	+	484	Protein_11	recombinase family protein	-
KU512_RS13285 (KU512_13270)	13513..13617	+	105	WP_001802298.1	hypothetical protein	Toxin
-	13613..13792	-	180	-	-	Antitoxin
KU512_RS13295 (KU512_13275)	14117..15208	-	1092	WP_000495671.1	lytic regulatory protein	-
KU512_RS13300 (KU512_13280)	15474..16454	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU512_RS13305 (KU512_13285)	16456..16776	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU512_RS13310 (KU512_13290)	16928..17593	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaZ	hld / groEL / hlb / map	1..256180	256180

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208703 WP_001802298.1 NZ_CP077935:13513-13617 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208703 NZ_CP103710:c4192802-4192425 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT208703 NZ_CP077935:c13792-13613 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin