Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1970382..1970905 Replicon chromosome
Accession NZ_CP077933
Organism Staphylococcus aureus strain 359

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag KU512_RS10165 Protein ID WP_000074048.1
Coordinates 1970382..1970648 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU512_RS10170 Protein ID WP_000587616.1
Coordinates 1970648..1970905 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU512_RS10145 (1965690) 1965690..1966877 - 1188 WP_000026194.1 MFS transporter -
KU512_RS10150 (1967273) 1967273..1968049 - 777 WP_050956485.1 iron export ABC transporter permease subunit FetB -
KU512_RS10155 (1968042) 1968042..1968704 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
KU512_RS10160 (1968951) 1968951..1970027 - 1077 WP_001076671.1 M42 family metallopeptidase -
KU512_RS10165 (1970382) 1970382..1970648 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
KU512_RS10170 (1970648) 1970648..1970905 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU512_RS10175 (1971011) 1971011..1971205 - 195 WP_001790145.1 hypothetical protein -
KU512_RS10180 (1971264) 1971264..1971719 + 456 WP_000732082.1 DUF1307 domain-containing protein -
KU512_RS10185 (1971887) 1971887..1973464 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KU512_RS10190 (1973659) 1973659..1974408 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
KU512_RS10195 (1974632) 1974632..1975825 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T208702 WP_000074048.1 NZ_CP077933:c1970648-1970382 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208702 NZ_CP103710:c4108356-4108069 [Escherichia coli O25b:H4-ST131]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208702 WP_000587616.1 NZ_CP077933:c1970905-1970648 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208702 NZ_CP103710:c4108082-4107780 [Escherichia coli O25b:H4-ST131]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References