Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1938885..1939069 Replicon chromosome
Accession NZ_CP077933
Organism Staphylococcus aureus strain 359

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag KU512_RS10025 Protein ID WP_000482650.1
Coordinates 1938962..1939069 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1938885..1938945 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU512_RS10010 1934415..1934582 - 168 WP_001790576.1 hypothetical protein -
KU512_RS10015 1934813..1936546 - 1734 WP_031833708.1 ABC transporter ATP-binding protein -
KU512_RS10020 1936571..1938334 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 1938885..1938945 + 61 - - Antitoxin
KU512_RS10025 1938962..1939069 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
KU512_RS10030 1939202..1939588 - 387 WP_000779358.1 flippase GtxA -
KU512_RS10035 1939856..1940998 + 1143 WP_001176863.1 glycerate kinase -
KU512_RS10040 1941058..1941717 + 660 WP_000831298.1 membrane protein -
KU512_RS10045 1941899..1943110 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU512_RS10050 1943233..1943706 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208700 WP_000482650.1 NZ_CP077933:c1939069-1938962 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208700 NZ_CP103710:3546357-3546575 [Escherichia coli O25b:H4-ST131]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT208700 NZ_CP077933:1938885-1938945 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References