Detailed information of TA system TA208695

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-sprA1AS/-
• Location: 592468..592775
• Replicon: chromosome
• Accession: NZ_CP077933
• Organism: Staphylococcus aureus strain 359

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU512_RS03200
• Protein ID: WP_011447039.1
• Coordinates: 592468..592644 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	592634..592775 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU512_RS03180	590298..590450	+	153	WP_001000058.1	hypothetical protein	-
KU512_RS03185	590496..590783	+	288	WP_001262621.1	hypothetical protein	-
KU512_RS03190	590839..591213	+	375	WP_000340977.1	hypothetical protein	-
KU512_RS03195	591586..592359	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KU512_RS03200	592468..592644	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	592634..592775	-	142	-	-	Antitoxin
KU512_RS03210	592856..593110	+	255	WP_000611512.1	phage holin	-
KU512_RS03215	593122..593877	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU512_RS03220	594068..594559	+	492	WP_000920038.1	staphylokinase	-
KU512_RS03225	595210..595545	+	336	Protein_622	SH3 domain-containing protein	-
KU512_RS03230	595790..595942	+	153	WP_001788502.1	hypothetical protein	-
KU512_RS03235	596013..596123	+	111	WP_000139423.1	hypothetical protein	-
KU512_RS03240	596125..596310	+	186	WP_001286805.1	hypothetical protein	-
KU512_RS03245	596946..597503	+	558	WP_000528632.1	PBECR4 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208695 WP_011447039.1 NZ_CP077933:592468-592644 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208695 NZ_CP103710:c1776045-1775671 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 142 bp

>AT208695 NZ_CP077933:c592775-592634 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin