Detailed information of TA system TA208681

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 2554279..2554586
• Replicon: chromosome
• Accession: NZ_CP077931
• Organism: Staphylococcus aureus strain 195

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU526_RS12450
• Protein ID: WP_011447039.1
• Coordinates: 2554279..2554455 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2554445..2554586 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU526_RS12430	2549514..2553299	+	3786	WP_000582165.1	phage tail spike protein	-
KU526_RS12435	2553289..2553441	+	153	WP_001153681.1	hypothetical protein	-
KU526_RS12440	2553488..2553775	+	288	WP_001040261.1	hypothetical protein	-
KU526_RS12445	2553833..2554129	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU526_RS12450	2554279..2554455	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2554445..2554586	-	142	-	-	Antitoxin
KU526_RS12460	2554667..2554921	+	255	WP_000611512.1	phage holin	-
KU526_RS12465	2554933..2555688	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU526_RS12470	2555879..2556370	+	492	WP_000919350.1	staphylokinase	-
KU526_RS12475	2557020..2557355	+	336	Protein_2462	SH3 domain-containing protein	-
KU526_RS12480	2557450..2557899	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU526_RS12485	2558584..2558934	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU526_RS12490	2558987..2559247	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2520719..2558934	38215

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208681 WP_011447039.1 NZ_CP077931:2554279-2554455 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208681 NZ_CP103704:c4227409-4227059 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT208681 NZ_CP077931:c2554586-2554445 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin