Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 978846..979260 | Replicon | chromosome |
| Accession | NZ_CP077931 | ||
| Organism | Staphylococcus aureus strain 195 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | KU526_RS04770 | Protein ID | WP_158171471.1 |
| Coordinates | 979009..979260 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KU526_RS04765 | Protein ID | WP_000028424.1 |
| Coordinates | 978846..979019 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU526_RS04725 (974880) | 974880..976103 | - | 1224 | WP_001037578.1 | PBSX family phage terminase large subunit | - |
| KU526_RS04730 (976096) | 976096..976590 | - | 495 | WP_000594088.1 | terminase small subunit | - |
| KU526_RS04735 (976944) | 976944..977345 | - | 402 | WP_000286968.1 | hypothetical protein | - |
| KU526_RS04740 (977346) | 977346..977519 | - | 174 | WP_000595256.1 | transcriptional activator RinB | - |
| KU526_RS04745 (977516) | 977516..977902 | - | 387 | WP_000592207.1 | hypothetical protein | - |
| KU526_RS04750 (977899) | 977899..978105 | - | 207 | WP_168751664.1 | DUF1381 domain-containing protein | - |
| KU526_RS04755 (978142) | 978142..978669 | - | 528 | WP_054192935.1 | dUTPase | - |
| KU526_RS04760 (978684) | 978684..978845 | - | 162 | WP_000889684.1 | hypothetical protein | - |
| KU526_RS04765 (978846) | 978846..979019 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| KU526_RS04770 (979009) | 979009..979260 | - | 252 | WP_158171471.1 | DUF1024 family protein | Toxin |
| KU526_RS04775 (979253) | 979253..979618 | - | 366 | WP_225798359.1 | acetyltransferase | - |
| KU526_RS04780 (979608) | 979608..979808 | - | 201 | WP_123157447.1 | hypothetical protein | - |
| KU526_RS04785 (979805) | 979805..980212 | - | 408 | WP_176323847.1 | hypothetical protein | - |
| KU526_RS04790 (980215) | 980215..980421 | - | 207 | WP_054192815.1 | hypothetical protein | - |
| KU526_RS04795 (980434) | 980434..980682 | - | 249 | WP_160194614.1 | phi PVL orf 51-like protein | - |
| KU526_RS04800 (980683) | 980683..981054 | - | 372 | WP_053005624.1 | SA1788 family PVL leukocidin-associated protein | - |
| KU526_RS04805 (981055) | 981055..981240 | - | 186 | WP_001187244.1 | DUF3113 family protein | - |
| KU526_RS04810 (981245) | 981245..981649 | - | 405 | WP_021758092.1 | DUF1064 domain-containing protein | - |
| KU526_RS04815 (981659) | 981659..981880 | - | 222 | WP_001123695.1 | DUF3269 family protein | - |
| KU526_RS04820 (981893) | 981893..982051 | - | 159 | WP_031929742.1 | hypothetical protein | - |
| KU526_RS04825 (982048) | 982048..982833 | - | 786 | WP_024273306.1 | ATP-binding protein | - |
| KU526_RS04830 (982846) | 982846..983667 | - | 822 | WP_225798360.1 | phage replisome organizer N-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp / sell / sec | 913831..995728 | 81897 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9463.35 Da Isoelectric Point: 3.6767
>T208675 WP_158171471.1 NZ_CP077931:c979260-979009 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY
Download Length: 252 bp
>T208675 NZ_CP103704:c2410462-2410286 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT208675 WP_000028424.1 NZ_CP077931:c979019-978846 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT208675 NZ_CP103704:c2410240-2409824 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|