Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 18084..18498 Replicon plasmid unnamed1
Accession NZ_CP077930
Organism Staphylococcus aureus strain 196

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU511_RS13950 Protein ID WP_158171471.1
Coordinates 18084..18335 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU511_RS13955 Protein ID WP_000028424.1
Coordinates 18325..18498 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU511_RS13890 (KU511_13840) 13677..14498 + 822 WP_225798360.1 phage replisome organizer N-terminal domain-containing protein -
KU511_RS13895 (KU511_13845) 14511..15296 + 786 WP_024273306.1 ATP-binding protein -
KU511_RS13900 (KU511_13850) 15293..15451 + 159 WP_031929742.1 hypothetical protein -
KU511_RS13905 (KU511_13855) 15464..15685 + 222 WP_001123695.1 DUF3269 family protein -
KU511_RS13910 (KU511_13860) 15695..16099 + 405 WP_021758092.1 DUF1064 domain-containing protein -
KU511_RS13915 (KU511_13865) 16104..16289 + 186 WP_001187244.1 DUF3113 family protein -
KU511_RS13920 (KU511_13870) 16290..16661 + 372 WP_053005624.1 SA1788 family PVL leukocidin-associated protein -
KU511_RS13925 (KU511_13875) 16662..16910 + 249 WP_160194614.1 phi PVL orf 51-like protein -
KU511_RS13930 (KU511_13880) 16923..17129 + 207 WP_054192815.1 hypothetical protein -
KU511_RS13935 (KU511_13885) 17132..17539 + 408 WP_176323847.1 hypothetical protein -
KU511_RS13940 (KU511_13890) 17536..17736 + 201 WP_123157447.1 hypothetical protein -
KU511_RS13945 (KU511_13895) 17726..18091 + 366 WP_225798359.1 acetyltransferase -
KU511_RS13950 (KU511_13900) 18084..18335 + 252 WP_158171471.1 DUF1024 family protein Toxin
KU511_RS13955 (KU511_13905) 18325..18498 + 174 WP_000028424.1 hypothetical protein Antitoxin
KU511_RS13960 (KU511_13910) 18499..18660 + 162 WP_000889684.1 hypothetical protein -
KU511_RS13965 (KU511_13915) 18675..19202 + 528 WP_054192935.1 dUTPase -
KU511_RS13970 (KU511_13920) 19239..19445 + 207 WP_168751664.1 DUF1381 domain-containing protein -
KU511_RS13975 (KU511_13925) 19442..19828 + 387 WP_000592207.1 hypothetical protein -
KU511_RS13980 (KU511_13930) 19825..19998 + 174 WP_000595256.1 transcriptional activator RinB -
KU511_RS13985 (KU511_13935) 19999..20400 + 402 WP_000286968.1 hypothetical protein -
KU511_RS13990 (KU511_13940) 20787..21248 + 462 WP_001794914.1 hypothetical protein -
KU511_RS13995 (KU511_13945) 21241..22464 + 1224 WP_001037578.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43105 43105


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9463.35 Da        Isoelectric Point: 3.6767

>T208672 WP_158171471.1 NZ_CP077930:18084-18335 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T208672 NZ_CP103704:c1821812-1821435 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACAGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT208672 WP_000028424.1 NZ_CP077930:18325-18498 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT208672 NZ_CP103704:c1822270-1821902 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References