Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1436782..1437196 Replicon chromosome
Accession NZ_CP077928
Organism Staphylococcus aureus strain 196

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU511_RS07290 Protein ID WP_158171471.1
Coordinates 1436945..1437196 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU511_RS07285 Protein ID WP_000028424.1
Coordinates 1436782..1436955 (-) Length 58 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU511_RS07245 (1432816) 1432816..1434039 - 1224 WP_001037578.1 PBSX family phage terminase large subunit -
KU511_RS07250 (1434032) 1434032..1434493 - 462 WP_001794914.1 hypothetical protein -
KU511_RS07255 (1434880) 1434880..1435281 - 402 WP_000286968.1 hypothetical protein -
KU511_RS07260 (1435282) 1435282..1435455 - 174 WP_000595256.1 transcriptional activator RinB -
KU511_RS07265 (1435452) 1435452..1435838 - 387 WP_000592207.1 hypothetical protein -
KU511_RS07270 (1435835) 1435835..1436041 - 207 WP_168751664.1 DUF1381 domain-containing protein -
KU511_RS07275 (1436078) 1436078..1436605 - 528 WP_054192935.1 dUTPase -
KU511_RS07280 (1436620) 1436620..1436781 - 162 WP_000889684.1 hypothetical protein -
KU511_RS07285 (1436782) 1436782..1436955 - 174 WP_000028424.1 hypothetical protein Antitoxin
KU511_RS07290 (1436945) 1436945..1437196 - 252 WP_158171471.1 DUF1024 family protein Toxin
KU511_RS07295 (1437189) 1437189..1437554 - 366 WP_225798359.1 acetyltransferase -
KU511_RS07300 (1437544) 1437544..1437744 - 201 WP_123157447.1 hypothetical protein -
KU511_RS07305 (1437741) 1437741..1438148 - 408 WP_176323847.1 hypothetical protein -
KU511_RS07310 (1438151) 1438151..1438357 - 207 WP_054192815.1 hypothetical protein -
KU511_RS07315 (1438370) 1438370..1438618 - 249 WP_160194614.1 phi PVL orf 51-like protein -
KU511_RS07320 (1438619) 1438619..1438990 - 372 WP_053005624.1 SA1788 family PVL leukocidin-associated protein -
KU511_RS07325 (1438991) 1438991..1439176 - 186 WP_001187244.1 DUF3113 family protein -
KU511_RS07330 (1439181) 1439181..1439585 - 405 WP_021758092.1 DUF1064 domain-containing protein -
KU511_RS07335 (1439595) 1439595..1439816 - 222 WP_001123695.1 DUF3269 family protein -
KU511_RS07340 (1439829) 1439829..1439987 - 159 WP_031929742.1 hypothetical protein -
KU511_RS07345 (1439984) 1439984..1440769 - 786 WP_024273306.1 ATP-binding protein -
KU511_RS07350 (1440782) 1440782..1441603 - 822 WP_225798360.1 phage replisome organizer N-terminal domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec 1371764..1450294 78530


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-82)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 9463.35 Da        Isoelectric Point: 3.6767

>T208671 WP_158171471.1 NZ_CP077928:c1437196-1436945 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T208671 NZ_CP103704:1808751-1809005 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT208671 WP_000028424.1 NZ_CP077928:c1436955-1436782 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT208671 NZ_CP103704:1808503-1808754 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References