Detailed information of TA system TA208667

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 257798..258105
• Replicon: chromosome
• Accession: NZ_CP077928
• Organism: Staphylococcus aureus strain 196

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU511_RS01350
• Protein ID: WP_011447039.1
• Coordinates: 257798..257974 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	257964..258105 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU511_RS01330	253033..256818	+	3786	WP_000582165.1	phage tail spike protein	-
KU511_RS01335	256808..256960	+	153	WP_001153681.1	hypothetical protein	-
KU511_RS01340	257007..257294	+	288	WP_001040261.1	hypothetical protein	-
KU511_RS01345	257352..257648	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU511_RS01350	257798..257974	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	257964..258105	-	142	-	-	Antitoxin
KU511_RS01360	258186..258440	+	255	WP_000611512.1	phage holin	-
KU511_RS01365	258452..259207	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU511_RS01370	259398..259889	+	492	WP_000919350.1	staphylokinase	-
KU511_RS01375	260539..260874	+	336	Protein_260	SH3 domain-containing protein	-
KU511_RS01380	260969..261418	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU511_RS01385	262103..262453	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU511_RS01390	262506..262766	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn	228449..262453	34004

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208667 WP_011447039.1 NZ_CP077928:257798-257974 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208667 NZ_CP103704:752616-752912 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT208667 NZ_CP077928:c258105-257964 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin