Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2500105..2500519 Replicon chromosome
Accession NZ_CP077926
Organism Staphylococcus aureus strain 197

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU504_RS12340 Protein ID WP_158171471.1
Coordinates 2500268..2500519 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU504_RS12335 Protein ID WP_000028424.1
Coordinates 2500105..2500278 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU504_RS12295 (2496139) 2496139..2497362 - 1224 WP_001037578.1 PBSX family phage terminase large subunit -
KU504_RS12300 (2497355) 2497355..2497816 - 462 WP_001794914.1 hypothetical protein -
KU504_RS12305 (2498203) 2498203..2498604 - 402 WP_000286968.1 hypothetical protein -
KU504_RS12310 (2498605) 2498605..2498778 - 174 WP_000595256.1 transcriptional activator RinB -
KU504_RS12315 (2498775) 2498775..2499161 - 387 WP_000592207.1 hypothetical protein -
KU504_RS12320 (2499158) 2499158..2499364 - 207 WP_168751664.1 DUF1381 domain-containing protein -
KU504_RS12325 (2499401) 2499401..2499928 - 528 WP_054192935.1 dUTPase -
KU504_RS12330 (2499943) 2499943..2500104 - 162 WP_000889684.1 hypothetical protein -
KU504_RS12335 (2500105) 2500105..2500278 - 174 WP_000028424.1 hypothetical protein Antitoxin
KU504_RS12340 (2500268) 2500268..2500519 - 252 WP_158171471.1 DUF1024 family protein Toxin
KU504_RS12345 (2500512) 2500512..2500877 - 366 WP_225798359.1 acetyltransferase -
KU504_RS12350 (2500867) 2500867..2501067 - 201 WP_123157447.1 hypothetical protein -
KU504_RS12355 (2501064) 2501064..2501471 - 408 WP_176323847.1 hypothetical protein -
KU504_RS12360 (2501474) 2501474..2501680 - 207 WP_054192815.1 hypothetical protein -
KU504_RS12365 (2501693) 2501693..2501941 - 249 WP_160194614.1 phi PVL orf 51-like protein -
KU504_RS12370 (2501942) 2501942..2502313 - 372 WP_053005624.1 SA1788 family PVL leukocidin-associated protein -
KU504_RS12375 (2502314) 2502314..2502499 - 186 WP_001187244.1 DUF3113 family protein -
KU504_RS12380 (2502504) 2502504..2502908 - 405 WP_021758092.1 DUF1064 domain-containing protein -
KU504_RS12385 (2502918) 2502918..2503139 - 222 WP_001123695.1 DUF3269 family protein -
KU504_RS12390 (2503152) 2503152..2503310 - 159 WP_031929742.1 hypothetical protein -
KU504_RS12395 (2503307) 2503307..2504092 - 786 WP_024273306.1 ATP-binding protein -
KU504_RS12400 (2504105) 2504105..2504926 - 822 WP_225798360.1 phage replisome organizer N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec 2435090..2516987 81897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9463.35 Da        Isoelectric Point: 3.6767

>T208661 WP_158171471.1 NZ_CP077926:c2500519-2500268 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T208661 NZ_CP103699:c4933348-4932431 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT208661 WP_000028424.1 NZ_CP077926:c2500278-2500105 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT208661 NZ_CP103699:c4934112-4933354 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References