Detailed information of TA system TA208657

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1321123..1321430
• Replicon: chromosome
• Accession: NZ_CP077926
• Organism: Staphylococcus aureus strain 197

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU504_RS06390
• Protein ID: WP_011447039.1
• Coordinates: 1321123..1321299 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1321289..1321430 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU504_RS06370	1316358..1320143	+	3786	WP_000582165.1	phage tail spike protein	-
KU504_RS06375	1320133..1320285	+	153	WP_001153681.1	hypothetical protein	-
KU504_RS06380	1320332..1320619	+	288	WP_001040261.1	hypothetical protein	-
KU504_RS06385	1320677..1320973	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU504_RS06390	1321123..1321299	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1321289..1321430	-	142	-	-	Antitoxin
KU504_RS06400	1321511..1321765	+	255	WP_000611512.1	phage holin	-
KU504_RS06405	1321777..1322532	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU504_RS06410	1322723..1323214	+	492	WP_000919350.1	staphylokinase	-
KU504_RS06415	1323864..1324199	+	336	Protein_1251	SH3 domain-containing protein	-
KU504_RS06420	1324294..1324743	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU504_RS06425	1325428..1325778	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU504_RS06430	1325831..1326091	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	1284598..1325778	41180

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208657 WP_011447039.1 NZ_CP077926:1321123-1321299 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208657 NZ_CP103699:4007269-4007487 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT208657 NZ_CP077926:c1321430-1321289 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin