Detailed information of TA system TA208648

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2105724..2106031
• Replicon: chromosome
• Accession: NZ_CP077925
• Organism: Staphylococcus aureus strain 198

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU531_RS10370
• Protein ID: WP_011447039.1
• Coordinates: 2105855..2106031 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2105724..2105863 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU531_RS10330 (2101063)	2101063..2101323	+	261	WP_001791826.1	hypothetical protein	-
KU531_RS10335 (2101376)	2101376..2101726	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU531_RS10340 (2102411)	2102411..2102860	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU531_RS10345 (2102955)	2102955..2103290	-	336	Protein_2007	SH3 domain-containing protein	-
KU531_RS10350 (2103940)	2103940..2104431	-	492	WP_000919350.1	staphylokinase	-
KU531_RS10355 (2104622)	2104622..2105377	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU531_RS10360 (2105389)	2105389..2105643	-	255	WP_000611512.1	phage holin	-
KU531_RS10365 (2105695)	2105695..2105802	+	108	WP_001791821.1	hypothetical protein	-
- (2105724)	2105724..2105863	+	140	NuclAT_0	-	Antitoxin
- (2105724)	2105724..2105863	+	140	NuclAT_0	-	Antitoxin
- (2105724)	2105724..2105863	+	140	NuclAT_0	-	Antitoxin
- (2105724)	2105724..2105863	+	140	NuclAT_0	-	Antitoxin
KU531_RS10370 (2105855)	2105855..2106031	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU531_RS10375 (2106181)	2106181..2106477	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU531_RS10380 (2106535)	2106535..2106822	-	288	WP_001040261.1	hypothetical protein	-
KU531_RS10385 (2106869)	2106869..2107021	-	153	WP_001153681.1	hypothetical protein	-
KU531_RS10390 (2107011)	2107011..2110796	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2101376..2139591	38215

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208648 WP_011447039.1 NZ_CP077925:c2106031-2105855 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208648 NZ_CP103697:4599312-4599659 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAATCGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT208648 NZ_CP077925:2105724-2105863 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin