Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 926636..927050 Replicon chromosome
Accession NZ_CP077925
Organism Staphylococcus aureus strain 198

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KU531_RS04420 Protein ID WP_158171471.1
Coordinates 926636..926887 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KU531_RS04425 Protein ID WP_000028424.1
Coordinates 926877..927050 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU531_RS04360 (922229) 922229..923050 + 822 WP_225798360.1 phage replisome organizer N-terminal domain-containing protein -
KU531_RS04365 (923063) 923063..923848 + 786 WP_024273306.1 ATP-binding protein -
KU531_RS04370 (923845) 923845..924003 + 159 WP_031929742.1 hypothetical protein -
KU531_RS04375 (924016) 924016..924237 + 222 WP_001123695.1 DUF3269 family protein -
KU531_RS04380 (924247) 924247..924651 + 405 WP_021758092.1 DUF1064 domain-containing protein -
KU531_RS04385 (924656) 924656..924841 + 186 WP_001187244.1 DUF3113 family protein -
KU531_RS04390 (924842) 924842..925213 + 372 WP_053005624.1 SA1788 family PVL leukocidin-associated protein -
KU531_RS04395 (925214) 925214..925462 + 249 WP_160194614.1 phi PVL orf 51-like protein -
KU531_RS04400 (925475) 925475..925681 + 207 WP_054192815.1 hypothetical protein -
KU531_RS04405 (925684) 925684..926091 + 408 WP_176323847.1 hypothetical protein -
KU531_RS04410 (926088) 926088..926288 + 201 WP_123157447.1 hypothetical protein -
KU531_RS04415 (926278) 926278..926643 + 366 WP_225798359.1 acetyltransferase -
KU531_RS04420 (926636) 926636..926887 + 252 WP_158171471.1 DUF1024 family protein Toxin
KU531_RS04425 (926877) 926877..927050 + 174 WP_000028424.1 hypothetical protein Antitoxin
KU531_RS04430 (927051) 927051..927212 + 162 WP_000889684.1 hypothetical protein -
KU531_RS04435 (927227) 927227..927754 + 528 WP_054192935.1 dUTPase -
KU531_RS04440 (927791) 927791..927997 + 207 WP_168751664.1 DUF1381 domain-containing protein -
KU531_RS04445 (927994) 927994..928380 + 387 WP_000592207.1 hypothetical protein -
KU531_RS04450 (928377) 928377..928550 + 174 WP_000595256.1 transcriptional activator RinB -
KU531_RS04455 (928551) 928551..928952 + 402 WP_000286968.1 hypothetical protein -
KU531_RS04460 (929339) 929339..929800 + 462 WP_001794914.1 hypothetical protein -
KU531_RS04465 (929793) 929793..931016 + 1224 WP_001037578.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell 910168..978027 67859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9463.35 Da        Isoelectric Point: 3.6767

>T208644 WP_158171471.1 NZ_CP077925:926636-926887 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIDLDEAVGIMVSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T208644 NZ_CP103697:c3713352-3712435 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCACTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT208644 WP_000028424.1 NZ_CP077925:926877-927050 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT208644 NZ_CP103697:c3714116-3713358 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References