Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 671414..671837 Replicon chromosome
Accession NZ_CP077924
Organism Staphylococcus aureus strain 200

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU536_RS03495 Protein ID WP_001065091.1
Coordinates 671414..671665 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU536_RS03500 Protein ID WP_000028422.1
Coordinates 671655..671837 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU536_RS03450 (666974) 666974..667894 + 921 WP_000138472.1 recombinase RecT -
KU536_RS03455 (667975) 667975..668592 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU536_RS03460 (668593) 668593..669063 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU536_RS03465 (669093) 669093..669977 + 885 WP_000148316.1 DnaD domain protein -
KU536_RS03470 (669984) 669984..670202 + 219 WP_000338530.1 hypothetical protein -
KU536_RS03475 (670211) 670211..670615 + 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
KU536_RS03480 (670628) 670628..670996 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU536_RS03485 (671000) 671000..671242 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU536_RS03490 (671254) 671254..671421 + 168 WP_001624242.1 hypothetical protein -
KU536_RS03495 (671414) 671414..671665 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU536_RS03500 (671655) 671655..671837 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU536_RS03505 (671830) 671830..672372 + 543 WP_000185660.1 dUTP pyrophosphatase -
KU536_RS03510 (672409) 672409..672615 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU536_RS03515 (672612) 672612..672998 + 387 WP_000592207.1 hypothetical protein -
KU536_RS03520 (672995) 672995..673144 + 150 WP_000595265.1 transcriptional activator RinB -
KU536_RS03525 (673144) 673144..673344 + 201 WP_000265043.1 DUF1514 family protein -
KU536_RS03530 (673372) 673372..673788 + 417 WP_000590122.1 hypothetical protein -
KU536_RS03535 (674020) 674020..674319 + 300 WP_000988336.1 HNH endonuclease -
KU536_RS03540 (674449) 674449..674793 + 345 WP_000402904.1 hypothetical protein -
KU536_RS03545 (674790) 674790..676451 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / chp / scn 646277..697247 50970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208635 WP_001065091.1 NZ_CP077924:671414-671665 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208635 NZ_CP103694:3970541-3970798 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGTTCGATAATCGCTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208635 WP_000028422.1 NZ_CP077924:671655-671837 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208635 NZ_CP103694:3970810-3971355 [Escherichia coli]
ATAACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACTGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References