Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 520613..520892 Replicon chromosome
Accession NZ_CP077924
Organism Staphylococcus aureus strain 200

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag KU536_RS02670 Protein ID WP_001802298.1
Coordinates 520613..520717 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 520713..520892 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU536_RS02645 516512..517120 + 609 WP_000101715.1 TIR domain-containing protein -
KU536_RS02650 517410..518192 + 783 WP_000908191.1 ABC transporter ATP-binding protein -
KU536_RS02655 518260..519117 + 858 WP_000370942.1 HAD family hydrolase -
KU536_RS02660 519247..519339 - 93 WP_000220902.1 hypothetical protein -
KU536_RS02665 519775..519933 - 159 WP_001792784.1 hypothetical protein -
KU536_RS02670 520613..520717 + 105 WP_001802298.1 hypothetical protein Toxin
- 520713..520892 - 180 - - Antitoxin
KU536_RS02680 521215..522306 - 1092 WP_000495673.1 hypothetical protein -
KU536_RS02685 522572..523552 - 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
KU536_RS02690 523554..523874 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
KU536_RS02695 524026..524691 + 666 WP_001024099.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T208630 WP_001802298.1 NZ_CP077924:520613-520717 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T208630 NZ_CP103694:2617146-2617253 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 180 bp

>AT208630 NZ_CP077924:c520892-520713 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References