Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 640937..641163 Replicon chromosome
Accession NZ_CP077923
Organism Staphylococcus aureus strain 201

Toxin (Protein)


Gene name SprG2 Uniprot ID A0A0E0VS87
Locus tag KU534_RS03370 Protein ID WP_000253688.1
Coordinates 640937..641044 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 641097..641163 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU534_RS03350 (636198) 636198..639878 + 3681 WP_000582140.1 phage tail spike protein -
KU534_RS03355 (639865) 639865..640017 + 153 WP_001181555.1 hypothetical protein -
KU534_RS03360 (640064) 640064..640351 + 288 WP_001040257.1 hypothetical protein -
KU534_RS03365 (640409) 640409..640705 + 297 WP_000539688.1 DUF2951 domain-containing protein -
KU534_RS03370 (640937) 640937..641044 + 108 WP_000253688.1 putative holin-like toxin Toxin
- (641097) 641097..641163 - 67 NuclAT_0 - Antitoxin
- (641097) 641097..641163 - 67 NuclAT_0 - Antitoxin
- (641097) 641097..641163 - 67 NuclAT_0 - Antitoxin
- (641097) 641097..641163 - 67 NuclAT_0 - Antitoxin
KU534_RS03375 (641088) 641088..641192 - 105 Protein_660 hypothetical protein -
KU534_RS03380 (641243) 641243..641545 + 303 WP_000387656.1 phage holin -
KU534_RS03385 (641557) 641557..643011 + 1455 WP_000930259.1 N-acetylmuramoyl-L-alanine amidase -
KU534_RS03390 (643106) 643106..643555 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU534_RS03395 (644240) 644240..644590 + 351 WP_000702263.1 complement inhibitor SCIN-A -
KU534_RS03400 (644643) 644643..644903 - 261 WP_001791826.1 hypothetical protein -
KU534_RS03405 (645214) 645214..645393 - 180 WP_000669789.1 hypothetical protein -
KU534_RS03410 (645765) 645765..645962 - 198 WP_000239614.1 phospholipase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / chp / scn 593620..644590 50970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3817.78 Da        Isoelectric Point: 10.4997

>T208619 WP_000253688.1 NZ_CP077923:640937-641044 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLSHKK

Download         Length: 108 bp

>T208619 NZ_CP103694:189468-189575 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT208619 NZ_CP077923:c641163-641097 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VS87

Antitoxin

Download structure file

References