Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 618757..619180 Replicon chromosome
Accession NZ_CP077923
Organism Staphylococcus aureus strain 201

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU534_RS03225 Protein ID WP_001065091.1
Coordinates 618757..619008 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU534_RS03230 Protein ID WP_000028422.1
Coordinates 618998..619180 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU534_RS03180 (614317) 614317..615237 + 921 WP_000138472.1 recombinase RecT -
KU534_RS03185 (615318) 615318..615935 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU534_RS03190 (615936) 615936..616406 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU534_RS03195 (616436) 616436..617320 + 885 WP_000148316.1 DnaD domain protein -
KU534_RS03200 (617327) 617327..617545 + 219 WP_000338530.1 hypothetical protein -
KU534_RS03205 (617554) 617554..617958 + 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
KU534_RS03210 (617971) 617971..618339 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU534_RS03215 (618343) 618343..618585 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU534_RS03220 (618591) 618591..618764 + 174 WP_001793974.1 hypothetical protein -
KU534_RS03225 (618757) 618757..619008 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU534_RS03230 (618998) 618998..619180 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU534_RS03235 (619173) 619173..619715 + 543 WP_000185660.1 dUTP pyrophosphatase -
KU534_RS03240 (619752) 619752..619958 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU534_RS03245 (619955) 619955..620341 + 387 WP_000592207.1 hypothetical protein -
KU534_RS03250 (620338) 620338..620487 + 150 WP_000595265.1 transcriptional activator RinB -
KU534_RS03255 (620487) 620487..620687 + 201 WP_000265043.1 DUF1514 family protein -
KU534_RS03260 (620715) 620715..621131 + 417 WP_000590122.1 hypothetical protein -
KU534_RS03265 (621363) 621363..621662 + 300 WP_000988336.1 HNH endonuclease -
KU534_RS03270 (621792) 621792..622136 + 345 WP_000402904.1 hypothetical protein -
KU534_RS03275 (622133) 622133..623794 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / chp / scn 593620..644590 50970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208618 WP_001065091.1 NZ_CP077923:618757-619008 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208618 NZ_CP103688:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208618 WP_000028422.1 NZ_CP077923:618998-619180 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208618 NZ_CP103688:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References