Detailed information of TA system TA208612

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 467956..468219
• Replicon: chromosome
• Accession: NZ_CP077923
• Organism: Staphylococcus aureus strain 201

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU534_RS02400
• Protein ID: WP_001802298.1
• Coordinates: 467956..468060 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	468055..468219 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU534_RS02375	463855..464463	+	609	WP_000101715.1	TIR domain-containing protein	-
KU534_RS02380	464753..465535	+	783	WP_000908191.1	ABC transporter ATP-binding protein	-
KU534_RS02385	465603..466460	+	858	WP_000370942.1	HAD family hydrolase	-
KU534_RS02390	466590..466682	-	93	WP_000220902.1	hypothetical protein	-
KU534_RS02395	467118..467276	-	159	WP_001792784.1	hypothetical protein	-
KU534_RS02400	467956..468060	+	105	WP_001802298.1	hypothetical protein	Toxin
-	468055..468219	-	165	-	-	Antitoxin
KU534_RS02410	468558..469649	-	1092	WP_000495673.1	hypothetical protein	-
KU534_RS02415	469915..470895	-	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
KU534_RS02420	470897..471217	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU534_RS02425	471369..472034	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208612 WP_001802298.1 NZ_CP077923:467956-468060 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208612 NZ_CP103687:4037398-4037616 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT208612 NZ_CP077923:c468219-468055 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin