Detailed information of TA system TA208610

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 172351..172535
• Replicon: chromosome
• Accession: NZ_CP077923
• Organism: Staphylococcus aureus strain 201

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU534_RS00850
• Protein ID: WP_000482647.1
• Coordinates: 172351..172458 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	172475..172535 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU534_RS00825	167708..168181	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
KU534_RS00830	168304..169515	-	1212	WP_001191974.1	multidrug effflux MFS transporter	-
KU534_RS00835	169703..170362	-	660	WP_000831300.1	hypothetical protein	-
KU534_RS00840	170422..171564	-	1143	WP_001176859.1	glycerate kinase	-
KU534_RS00845	171831..172217	+	387	WP_000779355.1	flippase GtxA	-
KU534_RS00850	172351..172458	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	172475..172535	-	61	-	-	Antitoxin
KU534_RS00855	173162..174925	+	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
KU534_RS00860	174950..176683	+	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
KU534_RS00865	176914..177081	+	168	WP_001798790.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208610 WP_000482647.1 NZ_CP077923:172351-172458 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208610 NZ_CP103687:2460795-2461112 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT208610 NZ_CP077923:c172535-172475 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin