Detailed information of TA system TA208608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1846707..1846891
• Replicon: chromosome
• Accession: NZ_CP077922
• Organism: Staphylococcus aureus strain 202

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU538_RS09310
• Protein ID: WP_000482647.1
• Coordinates: 1846784..1846891 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1846707..1846767 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU538_RS09295	1842161..1842328	-	168	WP_001798790.1	hypothetical protein	-
KU538_RS09300	1842559..1844292	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
KU538_RS09305	1844317..1846080	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	1846707..1846767	+	61	-	-	Antitoxin
KU538_RS09310	1846784..1846891	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU538_RS09315	1847025..1847411	-	387	WP_000779355.1	flippase GtxA	-
KU538_RS09320	1847678..1848820	+	1143	WP_001176859.1	glycerate kinase	-
KU538_RS09325	1848880..1849539	+	660	WP_000831300.1	hypothetical protein	-
KU538_RS09330	1849727..1850938	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
KU538_RS09335	1851061..1851534	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208608 WP_000482647.1 NZ_CP077922:c1846891-1846784 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208608 NZ_CP103687:796016-796426 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208608 NZ_CP077922:1846707-1846767 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin